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Article

TRPV1 Blocker, Peptide HCRG21 from Sea Anemone Heteractis magnifica, Exhibits Effectiveness in Psoriasis and Dermatitis in In Vivo Models

by
Anna Klimovich
1,†,
Aleksandra Kvetkina
1,†,
Yulia Deryavko
1,
Nadezhda Priymenko
1,2,
Daria Popkova
1,
Evgenia Bystritskaya
1,
Marina Isaeva
1,
Irina Gladkikh
1,
Oksana Sintsova
1 and
Elena Leychenko
1,2,*
1
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia
2
Advance Engineering School “Institute of Biotechnology, Bioengineering and Food Systems”, Far Eastern Federal University, 690920 Vladivostok, Russia
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2025, 26(21), 10644; https://doi.org/10.3390/ijms262110644
Submission received: 1 October 2025 / Revised: 29 October 2025 / Accepted: 29 October 2025 / Published: 31 October 2025
(This article belongs to the Special Issue Marine Natural Compounds: Biotechnological Potential and Pharmacological Targets)
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Abstract

Psoriasis and allergic contact dermatitis (ACD) are the most common chronic inflammatory diseases, which are accompanied by epithelial alterations and a T cell-mediated immunopathology. In this study, we investigated the anti-ACD and anti-psoriasis effects of sea anemone Heteractis magnifica peptide HCRG21, a blocker of the TRPV1 channel, in 2,4-dinitrofluorobenzene (DNFB)- and imiquimod (IMQ)-induced mouse models, respectively. We found that topical application of 0.005–0.1% HCRG21 gels normalized hematological and immunological blood parameters in mice, significantly reduced the severity of ACD- and psoriasiform-like skin lesions, and increased the rate of tissue repair. The use of 0.005 and 0.05% HCRG21 gels decreased the production of IL-23-A and macrophage-derived chemokine (MDC) proteins in blood plasma, reduced the expression of Tnf, Il1β, Il6, Il23a, and Il17a genes, but increased the levels of the Il10 gene in scabs and/or blood of IMQ-treated mice. On the other hand, topical application of 0.05 and 0.1% HCRG21 reduced the expression of Il6 and Il23a in the DNFB-treated mice’s blood and it had no significant effects on TNF-α and IL-1β production. Thus, HCRG21 has the potential to be a treatment for psoriasis and dermatitis due to its potent anti-inflammatory properties. This effect is achieved by reducing pro-inflammatory cytokines associated with TRPV1 and normalizing immune cell levels in the bloodstream. This, in turn, leads to a decrease in clinical symptoms and an improvement in skin healing.
Keywords: Kunitz-type peptide; TRPV1 channel; skin inflammation; psoriasis; allergic contact dermatitis; cytokines; imiquimod-induced model Kunitz-type peptide; TRPV1 channel; skin inflammation; psoriasis; allergic contact dermatitis; cytokines; imiquimod-induced model

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MDPI and ACS Style

Klimovich, A.; Kvetkina, A.; Deryavko, Y.; Priymenko, N.; Popkova, D.; Bystritskaya, E.; Isaeva, M.; Gladkikh, I.; Sintsova, O.; Leychenko, E. TRPV1 Blocker, Peptide HCRG21 from Sea Anemone Heteractis magnifica, Exhibits Effectiveness in Psoriasis and Dermatitis in In Vivo Models. Int. J. Mol. Sci. 2025, 26, 10644. https://doi.org/10.3390/ijms262110644

AMA Style

Klimovich A, Kvetkina A, Deryavko Y, Priymenko N, Popkova D, Bystritskaya E, Isaeva M, Gladkikh I, Sintsova O, Leychenko E. TRPV1 Blocker, Peptide HCRG21 from Sea Anemone Heteractis magnifica, Exhibits Effectiveness in Psoriasis and Dermatitis in In Vivo Models. International Journal of Molecular Sciences. 2025; 26(21):10644. https://doi.org/10.3390/ijms262110644

Chicago/Turabian Style

Klimovich, Anna, Aleksandra Kvetkina, Yulia Deryavko, Nadezhda Priymenko, Daria Popkova, Evgenia Bystritskaya, Marina Isaeva, Irina Gladkikh, Oksana Sintsova, and Elena Leychenko. 2025. "TRPV1 Blocker, Peptide HCRG21 from Sea Anemone Heteractis magnifica, Exhibits Effectiveness in Psoriasis and Dermatitis in In Vivo Models" International Journal of Molecular Sciences 26, no. 21: 10644. https://doi.org/10.3390/ijms262110644

APA Style

Klimovich, A., Kvetkina, A., Deryavko, Y., Priymenko, N., Popkova, D., Bystritskaya, E., Isaeva, M., Gladkikh, I., Sintsova, O., & Leychenko, E. (2025). TRPV1 Blocker, Peptide HCRG21 from Sea Anemone Heteractis magnifica, Exhibits Effectiveness in Psoriasis and Dermatitis in In Vivo Models. International Journal of Molecular Sciences, 26(21), 10644. https://doi.org/10.3390/ijms262110644

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