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Volume 26
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10.3390/ijms26178371
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Review

The Extracytoplasmic Protein Quality Control System in Pathogenic Campylobacterota: Its Role in Bacterial Virulence and Maintaining Cellular Envelope Proteostasis

by
Renata Godlewska
1,
Mateusz Weltrowski
2 and
Joanna Skórko-Glonek
2,*
1
Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland
2
Department of General and Medical Biochemistry, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(17), 8371; https://doi.org/10.3390/ijms26178371
Submission received: 24 July 2025 / Revised: 18 August 2025 / Accepted: 26 August 2025 / Published: 28 August 2025
(This article belongs to the Section Molecular Microbiology)
Versions Notes

Abstract

The cellular envelope of Gram-negative bacteria is a space where processes that are extremely important for the proper functioning of bacteria and determining their virulence take place. The extracytoplasmic protein quality control system, which includes chaperones, protein-folding catalysts, and proteases, is responsible for maintaining homeostasis in this cellular compartment. This system has been well studied in the model bacterium Escherichia coli, but little is known about its function in other bacteria. In bacteria evolutionarily distant from Enterobacteriaceae, the protein quality control system appears to function differently. For example, in the phylum Campylobacterota, a number of homologs of folding factors and proteases, whose functions are important for maintaining homeostasis in the periplasm of E. coli, have not been identified. Instead, there are quality control components that have no similar counterparts in the Enterobacteriaceae. In this review, we present the current state of knowledge on the extracytoplasmic protein quality control system in the model Campylobacterota, C. jejuni and H. pylori.
Keywords: protein quality control; protein folding; proteolysis; disulfide bonds; chaperones; virulence factors; Helicobacter pylori; Campylobacter jejuni protein quality control; protein folding; proteolysis; disulfide bonds; chaperones; virulence factors; Helicobacter pylori; Campylobacter jejuni

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MDPI and ACS Style

Godlewska, R.; Weltrowski, M.; Skórko-Glonek, J. The Extracytoplasmic Protein Quality Control System in Pathogenic Campylobacterota: Its Role in Bacterial Virulence and Maintaining Cellular Envelope Proteostasis. Int. J. Mol. Sci. 2025, 26, 8371. https://doi.org/10.3390/ijms26178371

AMA Style

Godlewska R, Weltrowski M, Skórko-Glonek J. The Extracytoplasmic Protein Quality Control System in Pathogenic Campylobacterota: Its Role in Bacterial Virulence and Maintaining Cellular Envelope Proteostasis. International Journal of Molecular Sciences. 2025; 26(17):8371. https://doi.org/10.3390/ijms26178371

Chicago/Turabian Style

Godlewska, Renata, Mateusz Weltrowski, and Joanna Skórko-Glonek. 2025. "The Extracytoplasmic Protein Quality Control System in Pathogenic Campylobacterota: Its Role in Bacterial Virulence and Maintaining Cellular Envelope Proteostasis" International Journal of Molecular Sciences 26, no. 17: 8371. https://doi.org/10.3390/ijms26178371

APA Style

Godlewska, R., Weltrowski, M., & Skórko-Glonek, J. (2025). The Extracytoplasmic Protein Quality Control System in Pathogenic Campylobacterota: Its Role in Bacterial Virulence and Maintaining Cellular Envelope Proteostasis. International Journal of Molecular Sciences, 26(17), 8371. https://doi.org/10.3390/ijms26178371

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