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Volume 26
Issue 17
10.3390/ijms26178190
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Review

Pyrazolo[5,1-c][1,2,4]triazole: A Promising Emerging Biologically Active Scaffold in Medicinal Chemistry

by
Beniamin-Nicolae Pintea
,
Vasilica-Georgiana Panțîr
,
Valentin Badea
* and
Francisc Péter
Department of Applied Chemistry and Engineering of Organic and Natural Compounds, Faculty of Chemical Engineering, Biotechnology, and Environmental Protection, University Politehnica Timișoara, Vasile Parvan Blv. 6, 300223 Timișoara, Romania
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(17), 8190; https://doi.org/10.3390/ijms26178190 (registering DOI)
Submission received: 27 June 2025 / Revised: 19 August 2025 / Accepted: 21 August 2025 / Published: 23 August 2025
(This article belongs to the Special Issue Heterocyclic Compounds: Synthesis, Design, and Biological Activity)
Versions Notes

Abstract

Nitrogen-containing heterocycles are essential compounds in nature, and their structural and functional diversity inspired the synthesis of a wide range of derivatives with diverse applications as pharmaceuticals, agrochemicals, dyes, polymers, cosmetics, etc. Among them, N-fused heterocycles represent an important category, due to their high potential as biologically active agents. Pyrazolo[5,1-c][1,2,4]triazoles, a class of nitrogen heterobicycles, have multiple applications as dyes and pigments. Also, a number of compounds containing this structure have been investigated for their biological activities. All the main experimental results published in the literature (both articles and patents) regarding the latter are summarized in this review.
Keywords: pyrazolo[5,1-c][1,2,4]triazoles; biological activity; toxicity pyrazolo[5,1-c][1,2,4]triazoles; biological activity; toxicity

Share and Cite

MDPI and ACS Style

Pintea, B.-N.; Panțîr, V.-G.; Badea, V.; Péter, F. Pyrazolo[5,1-c][1,2,4]triazole: A Promising Emerging Biologically Active Scaffold in Medicinal Chemistry. Int. J. Mol. Sci. 2025, 26, 8190. https://doi.org/10.3390/ijms26178190

AMA Style

Pintea B-N, Panțîr V-G, Badea V, Péter F. Pyrazolo[5,1-c][1,2,4]triazole: A Promising Emerging Biologically Active Scaffold in Medicinal Chemistry. International Journal of Molecular Sciences. 2025; 26(17):8190. https://doi.org/10.3390/ijms26178190

Chicago/Turabian Style

Pintea, Beniamin-Nicolae, Vasilica-Georgiana Panțîr, Valentin Badea, and Francisc Péter. 2025. "Pyrazolo[5,1-c][1,2,4]triazole: A Promising Emerging Biologically Active Scaffold in Medicinal Chemistry" International Journal of Molecular Sciences 26, no. 17: 8190. https://doi.org/10.3390/ijms26178190

APA Style

Pintea, B.-N., Panțîr, V.-G., Badea, V., & Péter, F. (2025). Pyrazolo[5,1-c][1,2,4]triazole: A Promising Emerging Biologically Active Scaffold in Medicinal Chemistry. International Journal of Molecular Sciences, 26(17), 8190. https://doi.org/10.3390/ijms26178190

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