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Volume 26
Issue 16
10.3390/ijms26167868
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

The Expanding Role of Omalizumab: From Food Allergy to Drug Desensitization

by
Bernadetta Kosztulska
1,
Magdalena Rydzyńska
1,
Zbigniew Bartuzi
2,
Magdalena Grześk-Kaczyńska
1 and
Natalia Ukleja-Sokołowska
2,*
1
Clinic of Allergology, Clinical Immunology and Internal Diseases, Jan Biziel University Hospital No. 2 in Bydgoszcz, Ujejskiego 75, 85-168 Bydgoszcz, Poland
2
Department and Clinic of Allergology, Clinical Immunology and Internal Diseases, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(16), 7868; https://doi.org/10.3390/ijms26167868
Submission received: 2 July 2025 / Revised: 7 August 2025 / Accepted: 12 August 2025 / Published: 14 August 2025
(This article belongs to the Special Issue Trends in Allergy and Autoimmunity: Pathogenesis, Biomarkers, and Treatment)
Versions Notes

Abstract

Although omalizumab is currently approved for a limited number of indications—such as asthma, chronic rhinosinusitis with nasal polyps, and chronic spontaneous urticaria—its potential applications are expanding each year. Owing to its diverse and not yet fully elucidated mechanism of action, including effects on both IgE- and non-IgE-mediated hypersensitivity reactions with delayed onset, this monoclonal antibody may be beneficial in a wide range of allergic and non-allergic conditions. To date, numerous clinical trials and case reports have documented the successful off-label use of omalizumab. It appears particularly promising for patients with difficult-to-treat hypersensitivities, such as food and drug allergies, which continue to pose significant challenges in modern allergology. Even though further research is needed to establish clear indications for its use in these contexts, omalizumab holds considerable potential to enhance the outcomes and clinical efficacy of food immunotherapy and drug desensitization protocols. The aim of this review is to present the current and potential future applications of omalizumab as an adjunctive treatment in food allergy therapy and in desensitization protocols for patients with hypersensitivity to selected drugs.
Keywords: allergy; omalizumab; food allergy; food allergy immunotherapy; drug hypersensitivity reactions; drug desensitization allergy; omalizumab; food allergy; food allergy immunotherapy; drug hypersensitivity reactions; drug desensitization

Share and Cite

MDPI and ACS Style

Kosztulska, B.; Rydzyńska, M.; Bartuzi, Z.; Grześk-Kaczyńska, M.; Ukleja-Sokołowska, N. The Expanding Role of Omalizumab: From Food Allergy to Drug Desensitization. Int. J. Mol. Sci. 2025, 26, 7868. https://doi.org/10.3390/ijms26167868

AMA Style

Kosztulska B, Rydzyńska M, Bartuzi Z, Grześk-Kaczyńska M, Ukleja-Sokołowska N. The Expanding Role of Omalizumab: From Food Allergy to Drug Desensitization. International Journal of Molecular Sciences. 2025; 26(16):7868. https://doi.org/10.3390/ijms26167868

Chicago/Turabian Style

Kosztulska, Bernadetta, Magdalena Rydzyńska, Zbigniew Bartuzi, Magdalena Grześk-Kaczyńska, and Natalia Ukleja-Sokołowska. 2025. "The Expanding Role of Omalizumab: From Food Allergy to Drug Desensitization" International Journal of Molecular Sciences 26, no. 16: 7868. https://doi.org/10.3390/ijms26167868

APA Style

Kosztulska, B., Rydzyńska, M., Bartuzi, Z., Grześk-Kaczyńska, M., & Ukleja-Sokołowska, N. (2025). The Expanding Role of Omalizumab: From Food Allergy to Drug Desensitization. International Journal of Molecular Sciences, 26(16), 7868. https://doi.org/10.3390/ijms26167868

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