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10.3390/ijms26167791
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Article

Therapeutic Effects of Sulforaphane on Helicobacter pylori-Infected Mice: Insights from High-Coverage Metabolomics and Lipidomics Analyses of Serum and Liver

by
Shuling He
1,†,
Lvyun Sun
1,
Jiali Chen
1,†,
Yixin Li
1,
Ying Pan
1,
Amei Su
1,
Qiuyao Mao
1,
Jiaqian Hu
1,
Disheng Feng
2,* and
Yang Ouyang
1,*
1
Department of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou 350122, China
2
Fujian Key Laboratory of Chinese Materia Medica, Institute of Structural Pharmacology & TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2025, 26(16), 7791; https://doi.org/10.3390/ijms26167791
Submission received: 21 June 2025 / Revised: 3 August 2025 / Accepted: 11 August 2025 / Published: 12 August 2025
(This article belongs to the Topic Nutrients, Food Bioactives, and Functional Foods in Gastrointestinal and Metabolic Disorders)
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Abstract

Sulforaphane, a natural isothiocyanate predominantly found in cruciferous vegetables, has shown potential in preventing and treating Helicobacter pylori infection. However, the underlying metabolic mechanisms remain largely unclear. This study employed high-coverage metabolomics and lipidomics methods to comprehensively investigate the effects of sulforaphane on the serum and liver metabolic profiles of H. pylori-infected mice. Metabolomics and lipidomics analysis revealed that H. pylori infection disrupted multiple metabolic pathways, leading to perturbations in amino acids, fatty acids, bile acids, and various lipid species. Sulforaphane treatment can ameliorate these disruptions, notably reversing alterations in serum glycerophospholipids and restoring hepatic levels of amino acids, bile acids, glycerophospholipids, ceramides, and peptides. Key metabolic pathways implicated included glutathione metabolism and glycine and serine metabolism, which are associated with antioxidant defense and host resistance to pathogenic infections. These findings offer a comprehensive metabolic basis for understanding the therapeutic effects of sulforaphane against H. pylori infection.
Keywords: sulforaphane; Helicobacter pylori; metabolomics; lipidomics sulforaphane; Helicobacter pylori; metabolomics; lipidomics

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MDPI and ACS Style

He, S.; Sun, L.; Chen, J.; Li, Y.; Pan, Y.; Su, A.; Mao, Q.; Hu, J.; Feng, D.; Ouyang, Y. Therapeutic Effects of Sulforaphane on Helicobacter pylori-Infected Mice: Insights from High-Coverage Metabolomics and Lipidomics Analyses of Serum and Liver. Int. J. Mol. Sci. 2025, 26, 7791. https://doi.org/10.3390/ijms26167791

AMA Style

He S, Sun L, Chen J, Li Y, Pan Y, Su A, Mao Q, Hu J, Feng D, Ouyang Y. Therapeutic Effects of Sulforaphane on Helicobacter pylori-Infected Mice: Insights from High-Coverage Metabolomics and Lipidomics Analyses of Serum and Liver. International Journal of Molecular Sciences. 2025; 26(16):7791. https://doi.org/10.3390/ijms26167791

Chicago/Turabian Style

He, Shuling, Lvyun Sun, Jiali Chen, Yixin Li, Ying Pan, Amei Su, Qiuyao Mao, Jiaqian Hu, Disheng Feng, and Yang Ouyang. 2025. "Therapeutic Effects of Sulforaphane on Helicobacter pylori-Infected Mice: Insights from High-Coverage Metabolomics and Lipidomics Analyses of Serum and Liver" International Journal of Molecular Sciences 26, no. 16: 7791. https://doi.org/10.3390/ijms26167791

APA Style

He, S., Sun, L., Chen, J., Li, Y., Pan, Y., Su, A., Mao, Q., Hu, J., Feng, D., & Ouyang, Y. (2025). Therapeutic Effects of Sulforaphane on Helicobacter pylori-Infected Mice: Insights from High-Coverage Metabolomics and Lipidomics Analyses of Serum and Liver. International Journal of Molecular Sciences, 26(16), 7791. https://doi.org/10.3390/ijms26167791

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