Next Article in Journal
Genetic Associations of ITGB3, FGG, GP1BA, PECAM1, and PEAR1 Polymorphisms and the Platelet Activation Pathway with Recurrent Pregnancy Loss in the Korean Population
Previous Article in Journal
CRISPR-Cas Gene Editing Technology in Potato
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 15
10.3390/ijms26157504
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Protective Efficacy of Lactobacillus plantarum Postbiotic beLP-K in a Dexamethasone-Induced Sarcopenia Model

by
Juyeong Moon
1,†,
Jin-Ho Lee
1,†,
Eunwoo Jeong
1,
Harang Park
1,
Hye-Yeong Song
1,
Jinsu Choi
1,
Min-ah Kim
1,
Kwon-Il Han
2,
Doyong Kim
3,
Han Sung Kim
3 and
Tack-Joong Kim
1,4,*
1
Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea
2
Research & Development Center, bereum Co. Ltd., Wonju 26362, Republic of Korea
3
Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea
4
Research & Development Center, Doctor TJ Co. Ltd., Wonju 26494, Republic of Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2025, 26(15), 7504; https://doi.org/10.3390/ijms26157504 (registering DOI)
Submission received: 19 June 2025 / Revised: 1 August 2025 / Accepted: 1 August 2025 / Published: 3 August 2025
(This article belongs to the Section Molecular Biology)
Versions Notes

Abstract

Sarcopenia is characterized by a reduction in muscle function and skeletal muscle mass relative to that of healthy individuals. In older adults and those who are less resistant to sarcopenia, glucocorticoid secretion or accumulation during treatment exacerbates muscle protein degradation, potentially causing sarcopenia. This study assessed the preventive effects and mechanisms of heat-killed Lactobacillus plantarum postbiotic beLP-K (beLP-K) against dexamethasone (DEX)-induced sarcopenia in C2C12 myotubes and Sprague-Dawley rats. The administration of beLP-K did not induce cytotoxicity and mitigated cell damage caused by DEX. Furthermore, beLP-K significantly reduced the expression of forkhead box O3 α (FoxO3α), muscle atrophy f-box (MAFbx)/atrogin-1, and muscle RING-finger protein-1 (MuRF1), which are associated with muscle protein degradation. DEX induced weight loss in rats; however, in the beLP-K group, weight gain was observed. Micro-computed tomography analysis revealed that beLP-K increased muscle mass, correlating with weight and grip strength. beLP-K alleviated the DEX-induced reduction in grip strength and increased the mass of hind leg muscles. The correlation between beLP-K administration and increased muscle mass was associated with decreased expression levels of muscle degradation-related proteins such as MAFbx/atrogin-1 and MuRF1. Therefore, beLP-K may serve as a treatment for sarcopenia or as functional food material.
Keywords: sarcopenia; Lactobacillus plantarum; postbiotic; beLP-K; dexamethasone; FoxO3α; MAFbx/atrogin-1; MuRF1 sarcopenia; Lactobacillus plantarum; postbiotic; beLP-K; dexamethasone; FoxO3α; MAFbx/atrogin-1; MuRF1

Share and Cite

MDPI and ACS Style

Moon, J.; Lee, J.-H.; Jeong, E.; Park, H.; Song, H.-Y.; Choi, J.; Kim, M.-a.; Han, K.-I.; Kim, D.; Kim, H.S.; et al. Protective Efficacy of Lactobacillus plantarum Postbiotic beLP-K in a Dexamethasone-Induced Sarcopenia Model. Int. J. Mol. Sci. 2025, 26, 7504. https://doi.org/10.3390/ijms26157504

AMA Style

Moon J, Lee J-H, Jeong E, Park H, Song H-Y, Choi J, Kim M-a, Han K-I, Kim D, Kim HS, et al. Protective Efficacy of Lactobacillus plantarum Postbiotic beLP-K in a Dexamethasone-Induced Sarcopenia Model. International Journal of Molecular Sciences. 2025; 26(15):7504. https://doi.org/10.3390/ijms26157504

Chicago/Turabian Style

Moon, Juyeong, Jin-Ho Lee, Eunwoo Jeong, Harang Park, Hye-Yeong Song, Jinsu Choi, Min-ah Kim, Kwon-Il Han, Doyong Kim, Han Sung Kim, and et al. 2025. "Protective Efficacy of Lactobacillus plantarum Postbiotic beLP-K in a Dexamethasone-Induced Sarcopenia Model" International Journal of Molecular Sciences 26, no. 15: 7504. https://doi.org/10.3390/ijms26157504

APA Style

Moon, J., Lee, J.-H., Jeong, E., Park, H., Song, H.-Y., Choi, J., Kim, M.-a., Han, K.-I., Kim, D., Kim, H. S., & Kim, T.-J. (2025). Protective Efficacy of Lactobacillus plantarum Postbiotic beLP-K in a Dexamethasone-Induced Sarcopenia Model. International Journal of Molecular Sciences, 26(15), 7504. https://doi.org/10.3390/ijms26157504

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop