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Volume 26
Issue 15
10.3390/ijms26157459
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Review
Peer-Review Record

Opioid Use in Cancer Pain Management: Navigating the Line Between Relief and Addiction

Int. J. Mol. Sci. 2025, 26(15), 7459; https://doi.org/10.3390/ijms26157459
by Maite Trullols and Vicenç Ruiz de Porras *
Reviewer 1:
Mostafa El-Miligy
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2025, 26(15), 7459; https://doi.org/10.3390/ijms26157459
Submission received: 15 July 2025 / Revised: 30 July 2025 / Accepted: 31 July 2025 / Published: 1 August 2025
(This article belongs to the Special Issue Recent Progress of Opioid Research, 2nd Edition)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

Most of the introduction part is talking about pain in general including cancer. It would be better to focus on the title of the review “Opioid Use in Cancer Pain Management”.

The review should focus on the role of different opioid drugs in management of cancer related pain clinically.

The review is missing comparison of the clinically used doses of different opioid drugs and their reported side effects besides which opioid drug is the best with less side effects.

correct 2.2.3.1. Morfine to Morphine 

 

 

Comments on the Quality of English Language

The English language should be revised carefully for typos and corrected.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

Hello, dear authors!

The review is dedicated to the current topic - the use of opioids to treat pain in cancer patients. I am impressed by an integrated approach to the problem where the authors discuss not only clinical pharmacology, but also raise issues of rational pharmacotherapy.

Nevertheless, I would like the authors to pay attention to the methods of evaluating pain. It can be psychological express tests, as well as hardware techniques. This inclusion is important, as it allows you to discuss tolerance to pain relief on the one hand, and on the other, to emphasize the problems of hyperalgesia and personal tolerance.

It will also be useful to make a small section about potential barriers to introduce recommended strategies in different healthcare systems

In this regard, it will be appropriate to make a graphic abstract, as well as supplement the list of literature

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

The authors responded adequately to the comments and the manuscript is now suitable for publication in the current revised form.

Thank you 

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