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Volume 25
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Review

Applications of Flow Cytometry in Drug Discovery and Translational Research

by
Sumana Ullas
and
Charles Sinclair
*
Flagship Pioneering, 140 First Street, Cambridge, MA 02141, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(7), 3851; https://doi.org/10.3390/ijms25073851
Submission received: 21 February 2024 / Revised: 23 March 2024 / Accepted: 27 March 2024 / Published: 29 March 2024
(This article belongs to the Special Issue Trends and Prospects of Flow Cytometry in Cell and Molecular Biology)
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Abstract

Flow cytometry is a mainstay technique in cell biology research, where it is used for phenotypic analysis of mixed cell populations. Quantitative approaches have unlocked a deeper value of flow cytometry in drug discovery research. As the number of drug modalities and druggable mechanisms increases, there is an increasing drive to identify meaningful biomarkers, evaluate the relationship between pharmacokinetics and pharmacodynamics (PK/PD), and translate these insights into the evaluation of patients enrolled in early clinical trials. In this review, we discuss emerging roles for flow cytometry in the translational setting that supports the transition and evaluation of novel compounds in the clinic.
Keywords: flow cytometry; drug discovery; cell biology; pharmacology; oncology; immunology; immuno-oncology; vaccines; translational research flow cytometry; drug discovery; cell biology; pharmacology; oncology; immunology; immuno-oncology; vaccines; translational research

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MDPI and ACS Style

Ullas, S.; Sinclair, C. Applications of Flow Cytometry in Drug Discovery and Translational Research. Int. J. Mol. Sci. 2024, 25, 3851. https://doi.org/10.3390/ijms25073851

AMA Style

Ullas S, Sinclair C. Applications of Flow Cytometry in Drug Discovery and Translational Research. International Journal of Molecular Sciences. 2024; 25(7):3851. https://doi.org/10.3390/ijms25073851

Chicago/Turabian Style

Ullas, Sumana, and Charles Sinclair. 2024. "Applications of Flow Cytometry in Drug Discovery and Translational Research" International Journal of Molecular Sciences 25, no. 7: 3851. https://doi.org/10.3390/ijms25073851

APA Style

Ullas, S., & Sinclair, C. (2024). Applications of Flow Cytometry in Drug Discovery and Translational Research. International Journal of Molecular Sciences, 25(7), 3851. https://doi.org/10.3390/ijms25073851

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