Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism
Abstract
:1. Introduction
2. Protective Role of Exercise against DN in Human Studies
3. Amelioration of DN by Exercise in Animal Studies
4. Molecular Mechanism of Exercise-Mediated Alleviation of DN
4.1. Role of Exercise-Mediated miR-181b Up-Regulation in Amelioration of DN
4.2. Role of Exercise-Regulated Renin–Angiotensin System in Amelioration of DN
4.3. Role of Exercise-Mediated Increase in Sirt1 in Amelioration of DN
4.4. Role of Exercise-Mediated Increase in NO in Amelioration of DN
4.5. Role of Exercise-Mediated Inhibition of P2X7 Receptors in Amelioration of DN
4.6. Role of Exercise-Mediated Increase in Heat Shock Protein in Amelioration of DN
4.7. Role of Exercise-Mediated Gut Microbiota Changes in Amelioration of DN
4.8. Role of Exercise-Induced Hormones and Metabolites in Amelioration of DN
4.8.1. Neuregulin 4 (Nrg4)
4.8.2. Irisin
4.8.3. Metrnl
4.8.4. β-Hydroxybutyrate (BHB)
4.8.5. β-Aminoisobutyric Acid (BAIBA)
4.8.6. Glucagon-like Peptide 1 (GLP-1)
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Li, R.-Y.; Guo, L. Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism. Int. J. Mol. Sci. 2024, 25, 3605. https://doi.org/10.3390/ijms25073605
Li R-Y, Guo L. Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism. International Journal of Molecular Sciences. 2024; 25(7):3605. https://doi.org/10.3390/ijms25073605
Chicago/Turabian StyleLi, Ruo-Ying, and Liang Guo. 2024. "Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism" International Journal of Molecular Sciences 25, no. 7: 3605. https://doi.org/10.3390/ijms25073605