Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats
Abstract
:1. Introduction
2. Results
2.1. General Locomotor and Exploratory Behavior
2.2. Locomotor Hyperactivity
2.3. Anxiety Level
2.4. Impulsivity (Tolerance Delay) in Modified T-Maze Test
2.5. Impulsive Water Drinking (in Aversive Electro Foot Shock Apparatus)
2.6. Neuroreceptor Quantity and Expression in Prefrontal Cortex, Striatum, and Substantia Nigra
2.6.1. Prefrontal Cortex
2.6.2. Striatum
2.7. Substantia Nigra
3. Discussion
3.1. 5-HT1A Agonist Effects
3.2. 5-HT2A Antagonism Effects
3.3. Alpha-2 Agonist Effects
3.4. Expression of DA Receptors
3.5. Involvement of the Striatum, Prefrontal Cortex, and the Substantia Nigra in ADHD
4. Materials and Methods
4.1. Animals
4.2. Experimental Design
4.3. Agonist and Antagonist Dose and Preparation
4.4. Behavioral Tests (for Assessment of ADHD)
4.4.1. General Locomotor and Exploratory Behavior in a Novel Environment
4.4.2. Locomotor Hyperactivity Assessment
4.4.3. Anxiety-like Behavior Assessment in Elevated plus Maze
4.4.4. Impulsivity Analysis in Modified T-Maze
4.4.5. Impulsivity Analysis in Electro Foot Shock Aversive Water Drinking Test (EFSDT)
4.5. Western Blotting
4.6. Immunohistochemistry
4.7. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Madhyastha, S.; Rao, M.S.; Renno, W.M. Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats. Int. J. Mol. Sci. 2024, 25, 2300. https://doi.org/10.3390/ijms25042300
Madhyastha S, Rao MS, Renno WM. Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats. International Journal of Molecular Sciences. 2024; 25(4):2300. https://doi.org/10.3390/ijms25042300
Chicago/Turabian StyleMadhyastha, Sampath, Muddanna S. Rao, and Waleed M. Renno. 2024. "Serotonergic and Adrenergic Neuroreceptor Manipulation Ameliorates Core Symptoms of ADHD through Modulating Dopaminergic Receptors in Spontaneously Hypertensive Rats" International Journal of Molecular Sciences 25, no. 4: 2300. https://doi.org/10.3390/ijms25042300