Variation of the 2D Pattern of Brain Proteins in Mice Infected with Taenia crassiceps ORF Strain
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Infection Time | N° Spot | ~MW Spot | ~IP Spot | Probable Protein | MW Protein | IP Protein | Refs. |
---|---|---|---|---|---|---|---|
Week 2 | 1 | 62.24 | 4.7 | Neurofilament protein NF-66 mRNA α-Internexin | 61 | 4.79 | [13] |
2 | 11.8 | 3.6 | U6 snRNA-associated Sm-like protein LSm3 | 11.8 | 4.08 | [14] | |
3 | 35 | 5.2 | Creatine kinase b-chain | 34.09 | 5.22 | [15] | |
4 | 21.11 | 5.1 | Lactoylglutathione Lyase Phosphatidylethanolamine-binding protein mRNA | 21 21 | 5.15 5.11 | [16,17] | |
5 | 23.66 | 5.45 | Glutathione S-transferase P 1 | 23.6 | 5.43 | [18] | |
6 | 22.78 | 5.7 | γ-Enolase | 25.24 | 5.73 | [19] | |
7 | 20 | 5.95 | Diphosphoinositol polyphosphate phosphohydrolase 2 Neuron-specific protein family member 1 | 20.16 20.93 | 5.99 5.99 | [20] | |
8 | 52 | 6.35 | tRNA modification GTPase GTPBP3, mitochondrial | 52.1 | 6.37 | [21] | |
9 | 48 | 6.2 | Basic leucine zipper and W2 domain-containing protein 2 | 48.06 | 6.26 | [22] | |
10 | 47 | 6.4 | Neuronal pentraxin-2 | 47.14 | 6.3 | [23] | |
11 | 14.2 | 6.3 | Gelsolin precursor, plasma | 17.13 | 6.21 | [24] | |
12 | 13.67 | 7.2 | Serum amyloid A-3 protein | 13.7 | 6.0, 6.4, 7.0, 7.4, 7.5, 8.0 | [25] | |
Infection Time | N° spot | ~MW spot | IP spot | Probable protein | MW protein | IP protein | |
Week 4 | 1 2 | 51.25 50.5 | 6.05 6.75 | Annexin VII (synexin) 4-aminobutyrat aminotransferanse, mitochondrial precursor | 50 52.83 | 6.02 6.78 | [26] [27] |
Infection Time | N° spot | ~MW spot | ~IP spot | Probable protein | MW protein | IP protein | |
1 | 118 | 4.79 | Apg-2 mRNA | 120 | 5.0 | [28] | |
2 | 96.67 | 5.6 | Ubiquitin carboxyl-terminal hydrolase | 96.7 | 5.42 | [29] | |
3 | 57.75 | 7.98 | ------------------------------------------------------------------------------- | ----- | ---- | ||
4 | 45.5 | 7.75 | LanC-like protein 1 Ethanolamine phosphotransferase 1 | 45.34 45.35 | 7.57 7.33 | [30] [31] | |
5 | 42 | 7.7 | Cytosolic acyl coenzyme A thioester hydrolase mRNA | 42.11 | 7.65 | [32] | |
6 | 29.5 | 7.45 | Adaptin ear-binding coat-associated protein 1 | 29.63 | 7.72 | [33] | |
Week 8 | 7 | 30 | 7.72 | Gap junction gamma-3 protein | 30.29 | 7.71 | [34] |
8 | 31.25 | 8.14 | Thymidine kinase 2, mitochondrial | 31.26 | 8.71 | [35] | |
9 | 29.5 | 8.38 | Glyceraldehide 3-phosphate deshydrogenase | 28.93 | 8.39 | [36] | |
10 | 33 | 8.85 | Alpha/beta hydrolase domain-containing protein 11 | 33.56 | 8.86 | [37] | |
11 | 34.5 | 9.15 | AMMECR1-like protein Protein N-terminal asparagine amidohydrolase | 34.52 34.59 | 9.18 9.07 | [38] [39] | |
12 | 27 | 9.18 | Mitochondrial fission factor Major prion protein | 27.22 27.98 | 9.1 9.13 | [40] [41] | |
13 | 28.75 | 9.4 | Peroxisomal membrane protein 11B | 28.72 | 9.68 | [42] | |
14 | 57.07 | 9.3 | Lysophospholipid acyltransferase LPCAT4 | 57.1 | 8.65 | [43] | |
15 | 12.33 | 5.0 | Eukaryotic translation initiation factor 4E-binding protein 1 | 12.33 | 5.32 | [44] |
Protein | Pathway | KEEG Code |
---|---|---|
Neurofilament protein NF-66 mRNA α-Internexin | Cytoskeleton | --- |
U6 snRNA-associated Sm-like protein LSm3 | RNA degradation | mmu:67678 |
Creatine kinase b-chain | Arginine and proline metabolism | mmu:12709 |
Lactoylglutathione Lyase | Pyruvate metabolism | mmu:109801 |
Phosphatidylethanolamine-binding protein mRNA | Peptidase inhibitors | mmu:23980 |
Glutathione S-transferase P 1 | Glutathione metabolism | mmu:14858 |
γ-Enolase | Glycolysis/Gluconeogenesis | mmu:13807 |
Diphosphoinositol polyphosphate phosphohydrolase 2 | Hydrolase | mmu:71207 |
Neuron-specific protein family member 1 | Membrane trafficking | rno:25247 |
tRNA modification GTPase GTPBP3, mitochondrial | Transfer Rna biogenesis | mmu:70359 |
Basic leucine zipper and W2 domain-containing protein 2 | Translation regulator | mmu:66912 |
Neuronal pentraxin-2 | Signaling proteins | --- |
Gelsolin precursor, plasma | Phagocytosis/Regulation of actin cytoskeleton | mmu:56320 |
Serum amyloid A-3 protein | Exosome | mmu:20210 |
Annexin VII (synexin) | Amyotrophic lateral sclerosis | mmu:11750 |
4-aminobutyrat aminotransferanse, mitochondrial precursor | Alanine, aspartate, and glutamate metabolism Valine, leucine, and isoleucine degradation Beta-Alanine metabolism Ropanoate metabolism Butanoate metabolism Metabolic pathways GABAergic synapse | mmu:268860 |
Apg-2 mRNA | Heat shock protein | --- |
Ubiquitin carboxyl-terminal hydrolase | DNA repair and recombination proteins Ubiquitin system | mmu:230484 |
LanC-like protein 1 | Glutathione metabolism | mmu:14768 |
Ethanolamine phosphotransferase 1 | Phosphonate and phosphinate metabolism Glycerophospholipid metabolism Ether lipid metabolism | mmu:99712 |
Cytosolic acyl coenzyme A thioester hydrolase mRNA | Fatty acid elongation Biosynthesis of unsaturated fatty acids Ovarian steroidogenesis | mmu:26897 |
Adaptin ear-binding coat-associated protein 1 | Membrane trafficking | mmu:67602 |
Gap junction gamma-3 protein | Pores ion channels | mmu:118446 |
Thymidine kinase 2, mitochondrial | Nucleotido metabolism | --- |
Glyceraldehide 3-phosphate deshydrogenase | Glycolysis/Gluconeogenesis Carbon metabolism Biosynthesis of amino acids Hif-1 signaling pathway Alzheimer’s disease | mmu:14433 |
Alpha/beta hydrolase domain-containing protein 11 | Serine peptidases | hsa:83451 |
Junctional adhesion molecule B | Cell adhesion molecules Tight junction Leukocyte transendothelial migration | mmu:67374 |
AMMECR1-like protein | Signaling proteins | mmu:225339 |
Protein N-terminal asparagine amidohydrolase | Ubiquitin system | mmu:18203 |
Mitochondrial fission factor | Mitochondrial biogenesis | mmu:75734 |
Major prion protein | Ferroptosis Prion disease—Mus musculus (house mouse) Pathways of neurodegeneration | mmu:19122 |
Peroxisomal membrane protein 11B | Peroxisome | mmu:18632 |
Lysophospholipid acyltransferase LPCAT4 | Glycerophospholipid metabolism Ether lipid metabolism | mmu:99010 |
Eukaryotic translation initiation factor 4E-binding protein 1 | Egfr tyrosine kinase inhibitor resistance Hif-1 signaling pathway Mtor signaling pathway Pi3k-Akt signaling pathway Longevity regulating pathway Insulin signaling pathway | mmu:13684 |
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Díaz-Zaragoza, M.; Hernández-Ávila, R.; Landa, A.; Ostoa-Saloma, P. Variation of the 2D Pattern of Brain Proteins in Mice Infected with Taenia crassiceps ORF Strain. Int. J. Mol. Sci. 2024, 25, 1460. https://doi.org/10.3390/ijms25031460
Díaz-Zaragoza M, Hernández-Ávila R, Landa A, Ostoa-Saloma P. Variation of the 2D Pattern of Brain Proteins in Mice Infected with Taenia crassiceps ORF Strain. International Journal of Molecular Sciences. 2024; 25(3):1460. https://doi.org/10.3390/ijms25031460
Chicago/Turabian StyleDíaz-Zaragoza, Mariana, Ricardo Hernández-Ávila, Abraham Landa, and Pedro Ostoa-Saloma. 2024. "Variation of the 2D Pattern of Brain Proteins in Mice Infected with Taenia crassiceps ORF Strain" International Journal of Molecular Sciences 25, no. 3: 1460. https://doi.org/10.3390/ijms25031460