The Multifaceted S100B Protein: A Role in Obesity and Diabetes?
Abstract
:1. Introduction
2. The S100B Protein
3. The S100B Protein in Adipose Tissue
4. S100B Protein in Obesity/Diabetes and Related Conditions
Human Blood or Experimental Model | Condition | S100B Behavior | Reference |
---|---|---|---|
Human blood | Overweight, visceral obesity, insulin resistance | Elevated levels | Steiner et al., 2010 [49] |
Human blood | Metabolic syndrome | Elevated levels | Kheirouri et al., 2018 [50] |
Human blood | High or low body mass index | Elevated or reduced | Steiner et al., 2010 [51] |
Human blood | Chronic starvation | Reduced levels normalizing with weight gain | Holtkamp et al., 2008 [52] |
Human blood | Oral glucose tolerance test | Inverse correlation with insulin secretion | Steiner et al., 2014 [53] |
Human blood | Insulin resistance | Elevated levels | Steiner et al., 2010 [51] |
Mouse blood and white adipose tissue | Diet-induced obesity | Elevated levels normalizing with weight loss | Buckman et al., 2014 [60] |
3T3-L1 adipocytes | Stimulation by TNF-a or murine RAW264.7 macrophage-conditioned media | Increased secretion | Fujiya et al., 2014 [63] |
Murine RAW264.7 macrophages | Wild-type | Induction of upregulation of TNF-a and M1 proinflammatory markers | Fujiya et al., 2014 [63] |
Diabetic OLETF rat | Wild-type | Expression with RAGE in Islet cells | Lee et al., 2010 [65] |
INS-1 cells and rat, pig, and human islets (b cells) | Wild-type | Induction of apoptosis | Lee et al., 2010 [65] |
S100B knockout mice | Untreated | Induction of resistance streptozotocin-derived diabetes | Mohammadzadeh et al., 2018 [66] |
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Experimental Model | Treatment | S100B Behavior | Reference |
---|---|---|---|
Rat epidydimal fat pads or Isolated adipocytes | Administration of epinephrine or ACTH | Release | Suzuki et al., 1984 [42] |
Rat epidydimal adipose tissue | Cathecolamine injection | Reduced content | Suzuki et al., 1984 [44] |
Rat epidydimal fat pads | Administration of insulin induced by epinephrine, ACTH, or isoproterenol | reduction in release | Suzuki and Kato 1985 [45] |
Epidydimal fat pads from diabetic or starved rats | Untreated | Increased release and reduced content | Suzuki and Kato 1985 [45] |
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Michetti, F.; Di Sante, G.; Clementi, M.E.; Valeriani, F.; Mandarano, M.; Ria, F.; Di Liddo, R.; Rende, M.; Romano Spica, V. The Multifaceted S100B Protein: A Role in Obesity and Diabetes? Int. J. Mol. Sci. 2024, 25, 776. https://doi.org/10.3390/ijms25020776
Michetti F, Di Sante G, Clementi ME, Valeriani F, Mandarano M, Ria F, Di Liddo R, Rende M, Romano Spica V. The Multifaceted S100B Protein: A Role in Obesity and Diabetes? International Journal of Molecular Sciences. 2024; 25(2):776. https://doi.org/10.3390/ijms25020776
Chicago/Turabian StyleMichetti, Fabrizio, Gabriele Di Sante, Maria Elisabetta Clementi, Federica Valeriani, Martina Mandarano, Francesco Ria, Rosa Di Liddo, Mario Rende, and Vincenzo Romano Spica. 2024. "The Multifaceted S100B Protein: A Role in Obesity and Diabetes?" International Journal of Molecular Sciences 25, no. 2: 776. https://doi.org/10.3390/ijms25020776