Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory
Abstract
:1. Introduction
2. Results
2.1. The Connection from the Hippocampus to the Barrel Cortex Is Strengthened after the Formation of Associative Memory
2.2. The Connections from the Barrel Cortex and Hippocampal CA1 Area to the Hippocampal CA3 Area Are Upregulated after the Formation of Associative Memory
2.3. The Knockdown of Neuroligin-3 in the Barrel Cortex Attenuates the Connection from the Hippocampus to the Barrel Cortex
2.4. The Knockdown of Neuroligin-3 in Hippocampal CA3 Attenuates the Connections from the Barrel Cortex to Hippocampal CA3, but Not from Hippocampal CA1 to CA3
3. Discussion
4. Materials and Methods
4.1. The Selection of Animals
4.2. The Study of Behavioral Tasks
4.3. The Injections of Adeno-Associated Retro Viruses
4.4. Neural Tracing by Adeno-Associated Retro Viruses
4.5. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Xiao, H.; Xu, Y.; Cui, S.; Wang, J.-H. Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory. Int. J. Mol. Sci. 2024, 25, 711. https://doi.org/10.3390/ijms25020711
Xiao H, Xu Y, Cui S, Wang J-H. Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory. International Journal of Molecular Sciences. 2024; 25(2):711. https://doi.org/10.3390/ijms25020711
Chicago/Turabian StyleXiao, Huajuan, Yang Xu, Shan Cui, and Jin-Hui Wang. 2024. "Neuroligin-3-Mediated Synapse Formation Strengthens Interactions between Hippocampus and Barrel Cortex in Associative Memory" International Journal of Molecular Sciences 25, no. 2: 711. https://doi.org/10.3390/ijms25020711