Plasma Exchange Reduces Aβ Levels in Plasma and Decreases Amyloid Plaques in the Brain in a Mouse Model of Alzheimer’s Disease
Abstract
:1. Introduction
2. Results
2.1. Plasma Exchange Prevents the Increase in Aβ Levels in Plasma
2.2. Plasma Exchange Prevents the Formation of Amyloid Plaques in the Brain
2.3. Plasma Exchange Modifies the Relative Frequencies of Aβ Plaque Size
3. Discussion
4. Materials and Methods
4.1. Animal Experiments
4.2. Plasma Exchange Procedure
4.3. Immunohistochemistry
4.4. Thioflavin-S Staining
4.5. Immunofluorescence
4.6. Image Analysis
4.7. Determination of the Levels of Aβ in Plasma and Brain via Enzyme-Linked Immunoassay (ELISA)
4.8. Statistics
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Ramirez, S.; Koerich, S.; Astudillo, N.; De Gregorio, N.; Al-Lahham, R.; Allison, T.; Rocha, N.P.; Wang, F.; Soto, C. Plasma Exchange Reduces Aβ Levels in Plasma and Decreases Amyloid Plaques in the Brain in a Mouse Model of Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 17087. https://doi.org/10.3390/ijms242317087
Ramirez S, Koerich S, Astudillo N, De Gregorio N, Al-Lahham R, Allison T, Rocha NP, Wang F, Soto C. Plasma Exchange Reduces Aβ Levels in Plasma and Decreases Amyloid Plaques in the Brain in a Mouse Model of Alzheimer’s Disease. International Journal of Molecular Sciences. 2023; 24(23):17087. https://doi.org/10.3390/ijms242317087
Chicago/Turabian StyleRamirez, Santiago, Suelyn Koerich, Natalia Astudillo, Nicole De Gregorio, Rabab Al-Lahham, Tyler Allison, Natalia Pessoa Rocha, Fei Wang, and Claudio Soto. 2023. "Plasma Exchange Reduces Aβ Levels in Plasma and Decreases Amyloid Plaques in the Brain in a Mouse Model of Alzheimer’s Disease" International Journal of Molecular Sciences 24, no. 23: 17087. https://doi.org/10.3390/ijms242317087