Molecular Signatures Integral to Natural Reprogramming in the Pigment Epithelium Cells after Retinal Detachment in Pleurodeles waltl
Abstract
:1. Introduction
2. Results
2.1. Similarities and Differences in Gene Expression in Normal RPE Cells and at the Early and Late Stages of RPE Regeneration
2.2. Changes in Gene Expression Activity in Retinal Cells at Different Stages of RPE Cell Reprogramming
2.3. Up-Regulated Genes at the Studied Stages of the RPE Reprogramming
2.4. Down-Regulated Genes at the Studied Stages of the RPE Reprogramming Process
3. Discussion
3.1. Molecular Characteristics of the Early Stages of RPE Reprogramming
3.2. Changes in the Biosynthetic Activity
3.3. Remodeling Proteins of the ECM and the Surface of RPE Cells
3.4. Immune Response Genes, Protoncogenes, and Tumor Suppressors
3.5. Metabolic- and Oxidative Stress-Related Cellular Processes
3.6. Proteins with a Chaperone Function
3.7. Chromatin Remodeling
3.8. Ribosome Biogenesis, RNA Translation, and Protein Processing
4. Materials and Methods
4.1. Newt Strain and Surgical Operations
4.2. Preparation of Tissue Samples
4.3. RNA Extraction
4.4. cDNA Library Construction
4.5. Sequencing
4.6. Transcriptome Assembly and Annotation
4.7. Data Analysis
4.8. Differential Gene Expression Analysis
4.9. Assessment of Nonrandom Enrichment of Signaling and Metabolic Cascades and GO-Biological Process
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Markitantova, Y.; Fokin, A.; Boguslavsky, D.; Simirskii, V.; Kulikov, A. Molecular Signatures Integral to Natural Reprogramming in the Pigment Epithelium Cells after Retinal Detachment in Pleurodeles waltl. Int. J. Mol. Sci. 2023, 24, 16940. https://doi.org/10.3390/ijms242316940
Markitantova Y, Fokin A, Boguslavsky D, Simirskii V, Kulikov A. Molecular Signatures Integral to Natural Reprogramming in the Pigment Epithelium Cells after Retinal Detachment in Pleurodeles waltl. International Journal of Molecular Sciences. 2023; 24(23):16940. https://doi.org/10.3390/ijms242316940
Chicago/Turabian StyleMarkitantova, Yuliya, Alexander Fokin, Dmitry Boguslavsky, Vladimir Simirskii, and Aleksey Kulikov. 2023. "Molecular Signatures Integral to Natural Reprogramming in the Pigment Epithelium Cells after Retinal Detachment in Pleurodeles waltl" International Journal of Molecular Sciences 24, no. 23: 16940. https://doi.org/10.3390/ijms242316940