Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases
Abstract
:1. Introduction
2. Mast Cells and CD8 T Cells in Tissue Homeostasis and Disease
2.1. Mast Cells
2.2. CD8 T Cells
Characteristic | TRM Cells | Recirculating Cells | Ref. | |
---|---|---|---|---|
Trafficking property | Skin-resident | Skin-transient | [10] | |
Percentage (%) of CD8 T cells in healthy human skin | Epidermis | 25% | <5% | [51] |
Dermis | 13% | <5% | ||
Surface markers in skin | CD103+/−CD69+CD49a+/− | CD69− | [58] | |
Requirement for persistency in skin | TGF-β, IL-15/IL-7 | TGF-β, IL-15 | [56,74,75] | |
Effector function | CD103+ > CD103− | Limited | [51,76] | |
Proliferative capacity | CD103− > CD103+ | TCM > TEM | ||
Antiviral protection | Critical for secondary infection | Required for optimal response | [77] |
2.3. Modalities of Mast Cell-CD8 T Cell Interplay in the Skin
3. Modalities of Mast Cell–CD8 T Cell Interactions in the Skin: Cell–Cell Contact
3.1. MHC-TCR Mediated Mast Cell–CD8 T Cell Interactions
3.2. Costimulatory Molecule-Mediated Mast Cell–CD8 T Cell Interactions
3.2.1. CD28-CD80/CD86 Ligation
3.2.2. CD28-CD80/86 Ligation in Psoriasis
3.2.3. CD28-CD80/CD86 Ligation in Mast-Cell-Mediated CD8 T Cell Activation
3.2.4. OX40-OX40L
3.2.5. OX40-OX40 Ligation in Atopic Dermatitis
3.3. Soluble Mediators in Mast Cell–CD8 T Cell Interactions
Mediators Signalling in Vitiligo
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
AA | alopecia areata |
AD | atopic dermatitis |
APC | antigen-presenting cells |
AJ | adherens junctions |
BMMC | bone-marrow-derived mast cells |
CLA | cutaneous lymphocyte-associated antigen |
CCL | CC chemokine ligand |
CCR | CC chemokine receptor |
CHS | cutaneous contact hypersensitivity |
CTLA | cutaneous lymphocyte-associated antigen |
CRC | colorectal cancer |
CXCR | C-X-C chemokine receptor |
CXCL | C-X-C chemokine ligand |
CLT | cytotoxic lymphocyte-associated antigen-4 |
DAMP | damage/danger-associated molecular pattern |
DC | dendritic cells |
EASI | Eczema Area and Severity Index |
FcεRI | high-affinity IgE Fc receptor |
GBD | Global Burden of Disease |
Grb2 | growth factor receptor-bound protein 2 |
GWAS | genome-wide association studies |
IgICAM-1 | immunoglobulinintracellular adhesion receptor 1 |
IS | immunological synapse |
IL | interleukin |
LAMP-1 | lysosomal-associated membrane protein-1 |
LCMV | lymphocytic choriomeningitis virus |
LFA-1 | lymphocyte function-associated antigen-1 |
LTB4 | leukotriene B4 |
MAPK | mitogen-activated protein kinase |
MC | mast cell |
MHC | major histocompatibility complex |
NF-κB | nuclear factor-κB |
NK | natural killer |
OVA | ovalbumin |
PGD2 | prostaglandin D2 |
PI3K | phosphatidylinositol-3-kinase |
PKB/Akt | protein kinase B |
pMHC | peptide-MHC |
PUVA | psoralen and ultraviolet light A |
RAF | rapidly accelerated fibrosarcoma |
RAS | rat sarcoma |
S1PR1 | sphingosine-1-phosphate receptor 1 |
SCF | stem cell factor |
VEGF | vascular endothelial growth factor |
TGF-β | transforming growth factor-β |
TLR3 | toll-like receptor 3 |
TNF | tumour necrosis factor |
TNFR | tumour necrosis factor receptor |
TNRSF | TNF receptor superfamilies |
TNSF | TNF superfamilies |
TCM | central memory T cells |
TEM | effector memory T cells |
TRM | resident memory T cells |
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CD8 T Cell Receptors | MC Ligands | Receptor Family | Disease | Ref. |
---|---|---|---|---|
CD28 | CD80 (B7-1); CD86 (B7-2) | IgG-CD28/B7 | psoriasis | [117] |
OX40 (CD134) | OX40L (CD252) | TNF/TNFR | atopic dermatitis; alopecia areata | [33,118] |
4-1BB (CD137) | 4-1BBL | TNF/TNFR | psoriasis | [119] |
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Chen, Y.; Griffiths, C.E.M.; Bulfone-Paus, S. Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases. Int. J. Mol. Sci. 2023, 24, 1564. https://doi.org/10.3390/ijms24021564
Chen Y, Griffiths CEM, Bulfone-Paus S. Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases. International Journal of Molecular Sciences. 2023; 24(2):1564. https://doi.org/10.3390/ijms24021564
Chicago/Turabian StyleChen, Yiqiao, Christopher E. M. Griffiths, and Silvia Bulfone-Paus. 2023. "Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases" International Journal of Molecular Sciences 24, no. 2: 1564. https://doi.org/10.3390/ijms24021564