Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some?
Abstract
:1. Introduction
2. Results
2.1. Panel Characteristics
2.2. Chemosensory Phenotypes
2.3. Genetic Associations with Chemosensory Phenotypes
3. Discussion
4. Materials and Methods
4.1. Participants and Stimuli
4.2. Phenotyping
4.3. Genotyping, Genetic Ancestry, and Candidate Single-Nucleotide Polymorphisms (SNPs)
4.4. Statistical Analyses
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
References
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Experimental Condition | p Value 2 | ||||
---|---|---|---|---|---|
Sip & Spit | Swallow | Delay | Sip v Swallow | Sip v Delay | |
Intensity, gLMS rating | |||||
Sweetness | 33.9 ± 1.6 | 31.3 ± 1.6 | 16.4 ± 1.3 | 0.02 | 0.001 |
Irritation | 6.7 ± 0.7 | 10.9 ± 1.0 | 8.9 ± 1.0 | <0.001 | 0.02 |
Bitterness | 7.3 ± 0.8 | 8.6 ± 0.8 | 6.6 ± 0.8 | 0.03 | 0.34 |
Palatability | |||||
Hedonic gLMS rating | 16.4 ± 2.1 | 10.4 ± 2.2 | 8.2 ± 2.1 | <0.001 | 0.06 |
Gene | SNP Identifier/ Function | Major/Minor Allele 1 | Minor Allele Frequency | Phenotype, Stimulus 2 | SNP-Phenotype p Value 3 | SNP-Phenotype, Linear or Logistic Regression 4 | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
All Ancestries | African Ancestry | European Ancestry | Nonadjusted | PC Adjusted | |||||||
Effect Size | p Value | Effect Size | p Value | ||||||||
TRPM8 | rs7593557/S419N | G/A | 0.326 | 0.563 | 0.049 | Sweet rating, Motrin | 0.02 | 5.92 ± 2.15 | 0.007 | 3.49 ± 2.88 | 0.23 |
Cough/scratch, Motrin | 0.009 | 0.49 (0.30–0.77) | 0.003 | 0.60 (0.32–1.10) | 0.10 | ||||||
TRPV1 | rs224534/T469I | G/A | 0.28 | 0.143 | 0.324 | Tingle, Motrin | 0.04 | — | 0.23 | — | 0.96 |
TRPA1 | rs11988795/Intronic | C/T | 0.337 | 0.310 | 0.353 | Tingle, Motrin | 0.06 | 1.88 (1.12–3.23) | 0.02 | 1.80 (1.05–3.15) | 0.03 |
TAS1R3 | rs35744813/Intergenic | C/T | 0.369 | 0.619 | 0.127 | Sweet rating, Ace-K | 0.01 | — | 0.46 | — | 0.74 |
Sweet rating, sucrose | 0.07 | — | 0.18 | — | 0.93 | ||||||
TAS2R9 | rs3741845/V187A | A/G | 0.426 | 0.222 | 0.569 | Bitter rating, Ace-K | <0.001 | −0.99 ± 0.21 | <0.001 | −1.00 ± 0.25 | <0.001 |
TAS2R31 | rs10845293 A227V/ | G/A | 0.39 | 0.325 | 0.510 | Bitter rating, Ace-K | 0.002 | 0.69 ± 0.23 | 0.003 | 0.78 ± 0.23 | 0.001 |
TAS2R38 | rs713598/A49P | C/G | 0.465 | 0.508 | 0.412 | Bitter rating, PTU | <0.001 | 1.72 ± 0.24 | <0.001 | 1.73 ± 0.25 | <0.001 |
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Mennella, J.A.; Kan, M.; Lowenthal, E.D.; Saraiva, L.R.; Mainland, J.D.; Himes, B.E.; Pepino, M.Y. Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some? Int. J. Mol. Sci. 2023, 24, 13050. https://doi.org/10.3390/ijms241713050
Mennella JA, Kan M, Lowenthal ED, Saraiva LR, Mainland JD, Himes BE, Pepino MY. Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some? International Journal of Molecular Sciences. 2023; 24(17):13050. https://doi.org/10.3390/ijms241713050
Chicago/Turabian StyleMennella, Julie A., Mengyuan Kan, Elizabeth D. Lowenthal, Luis R. Saraiva, Joel D. Mainland, Blanca E. Himes, and M. Yanina Pepino. 2023. "Genetic Variation and Sensory Perception of a Pediatric Formulation of Ibuprofen: Can a Medicine Taste Too Good for Some?" International Journal of Molecular Sciences 24, no. 17: 13050. https://doi.org/10.3390/ijms241713050