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Volume 24
Issue 13
10.3390/ijms241310801
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Article
Peer-Review Record

Diagnostic and Prognostic Value of PACAP in Multiple Myeloma

Int. J. Mol. Sci. 2023, 24(13), 10801; https://doi.org/10.3390/ijms241310801
by Tünde Tóth 1, Hussain Alizadeh 2, Beáta Polgár 3, Renáta Csalódi 4, Dóra Reglődi 1 and Andrea Tamás 1,*
Reviewer 1:
Anna Furlan
Reviewer 2:
Prisco Marina
Reviewer 3: Anonymous
Int. J. Mol. Sci. 2023, 24(13), 10801; https://doi.org/10.3390/ijms241310801
Submission received: 24 March 2023 / Revised: 21 June 2023 / Accepted: 26 June 2023 / Published: 28 June 2023
(This article belongs to the Special Issue The Roles of VIP and PACAP: From Molecular and Genetic Studies)

Round 1

Reviewer 1 Report

Please see attachment

Comments for author File: Comments.docx

Author Response

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Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript is very interesting, rich in data and convincing in its conclusions. I found no weak points and believe it is publishable in this form.
My only request concerns the histological analyses that are mentioned in line 214 and that also in the materials and methods are not described in any way (line 609): the authors should better specify what analysis it is

Author Response

Please see attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

Numerous articles have been published on PACAP-38 in plasma and this article concerns multiple myeloma (MM).  By ELISA, PACAP-38 levels decreased approximately 30% in 66 MM patients relative to 10 controls.  Previous low levels of PACAP-38 were found in colon carcinoma, non-small cell lung cancer, renal tumors, thyroid carcinoma, pituitary adenomas and pancreatic adenocarcinomas.  PACAP-38 was not altered as a function of sex or age, but did correlate with progression free survival after autologous stem cell transplantation.  The plasma PACAP-38 levels were lower in MM patients with active disease relative to those patients in remission.  The manuscript is well written with good statistical analysis, however, the number of patients needs to be increased.  Major revision is required.

1.  Low numbers of patients (<10) are plotted in parts of Fig. 5, 7 and 8 (Mislabeled Fig. 9).  These figures need to be redone with more patients.

2. PACAP-38 levels correlate with prognosis of MM, however, more patients are needed to evaluate diagnosis.  The sensitivity and specificity need to be determined.  Because PACAP-38 levels are lower in other types of cancer, there may be a problem with false positives.

Author Response

Please see attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Dear Authors,

Please see attachment. Thank you

Comments for author File: Comments.docx

Author Response

Dear Reviewer,

Please see the attachment.

Kind regards,

The authors

Author Response File: Author Response.pdf

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