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Review

Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses

1
Charles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia
2
School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW 2006, Australia
3
School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia
4
Sydney Nano Institute, The University of Sydney, Camperdown, NSW 2006, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Alessandro Castorina
Int. J. Mol. Sci. 2022, 23(6), 3389; https://doi.org/10.3390/ijms23063389
Received: 24 February 2022 / Accepted: 16 March 2022 / Published: 21 March 2022
The discovery that cells secrete extracellular vesicles (EVs), which carry a variety of regulatory proteins, nucleic acids, and lipids, has shed light on the sophisticated manner by which cells can communicate and accordingly function. The bioactivity of EVs is not only defined by their internal content, but also through their surface associated molecules, and the linked downstream signaling effects they elicit in target cells. The extracellular matrix (ECM) contains signaling and structural molecules that are central to tissue maintenance and repair. Recently, a subset of EVs residing within the extracellular matrix has been identified. Although some roles have been proposed for matrix-bound vesicles, their role as signaling molecules within the ECM is yet to be explored. Given the close association of EVs and the ECM, it is not surprising that EVs partly mediate repair and regeneration by modulating matrix deposition and degradation through their cellular targets. This review addresses unique EV features that allow them to interact with and navigate through the ECM, describes how their release and content is influenced by the ECM, and emphasizes the emerging role of stem-cell derived EVs in tissue repair and regeneration through their matrix-modulating properties. View Full-Text
Keywords: extracellular vesicles; exosomes; microvesicles; extracellular matrix; mesenchymal stem cells; wound healing; tissue repair; matrix-bound vesicles extracellular vesicles; exosomes; microvesicles; extracellular matrix; mesenchymal stem cells; wound healing; tissue repair; matrix-bound vesicles
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MDPI and ACS Style

Al Halawani, A.; Mithieux, S.M.; Yeo, G.C.; Hosseini-Beheshti, E.; Weiss, A.S. Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses. Int. J. Mol. Sci. 2022, 23, 3389. https://doi.org/10.3390/ijms23063389

AMA Style

Al Halawani A, Mithieux SM, Yeo GC, Hosseini-Beheshti E, Weiss AS. Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses. International Journal of Molecular Sciences. 2022; 23(6):3389. https://doi.org/10.3390/ijms23063389

Chicago/Turabian Style

Al Halawani, Aleen, Suzanne M. Mithieux, Giselle C. Yeo, Elham Hosseini-Beheshti, and Anthony S. Weiss. 2022. "Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses" International Journal of Molecular Sciences 23, no. 6: 3389. https://doi.org/10.3390/ijms23063389

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