Use of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Results
2.1. Search Results
2.2. Synthesis of Results
2.3. Risk of Bias Assessments for In Vitro Studies
2.4. Meta-Analysis
3. Discussion
4. Materials and Methods
4.1. Protocol and Registration
4.2. Data Extraction and Research Question
4.3. Eligibility Criteria
4.4. Search Strategy
4.5. Meta-Analysis and Quantitative Approaches
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Study (Year) | Study Design | Peptide | Irradiation Time | Wavelength | Photosensitizer | Microorganism | Culture Type | Sample Size | Outcomes |
---|---|---|---|---|---|---|---|---|---|
Bourré et al. 2010 [14] | In vitro | Tat | 30, 43, 60, and 120 s | 410 nm | Tetracks (phenol) and porphyrin | Escherichia coli Staphylococcus aureus Pseudomonas aeruginosa Streptococcus pyogenes | Suspension | ND | Reduction in the concentration of 1 uM from 3 to 6 log10 CFU/mL. The greatest effect was in the first 30 s. |
Yang et al. 2011 [15] | In vitro | WLBU2 | 100 s | 652 nm | Temoporfin + WLBU2 | S. aureus (methicillin resistant) P. aeruginosa | Suspension | 3 | Reduction by 100% for S. aureus (aPDT only and aPDT + peptide) and reduction by 2 log10 CFU/mL for P. aeruginosa (aPDT + peptide). |
Liu et al. 2012 [16] | In vitro | WI13WF (YVLWKRKRKFCFI-amide) | 2, 5, and 10 min | 400 to 900 nm | Protoporphyrin IX | E. coli Salmonella enteric Klebsiella pneumoniae | Suspension | ND | Peptide and PS conjugate 99% lethal. |
Dosseli et al. 2013 [17] | In vitro | Apidaecin | ND | 600–750 nm 390–460 nm | Porphyrin | E. coli S. aureus | Suspension | ND | Reduction by 100% for E. coli. |
Johnson et al. 2013 [18] | In vitro | (KLAKLAK)2 | 30 min | 525 nm | (KLAKLAK)2 + Eosin Y | Acinetobacter baumannii P. aeruginosa E. coli S. aureus Staphylococcus epidermidis | Suspension | ND | Reduction by 99% for all microorganisms. |
Dosseli et al. 2014 [19] | In vitro | Magainin Buforin | ND | 390–460 nm | Porphyrin | E. coli S. aureus (methicillin resistant) | Suspension | ND | Reduction by 100% for all microorganisms. |
Johnson et al. 2014 [20] | In vitro | (KLAKLAK)2 | 2 min 5 min 30 min | 525 nm | (KLAKLAK)2 + Eosin Y | E. coli S. aureus | Suspension | 3 | Reduction by 50% for all microorganisms (2 min of irradiation). Reduction by 90% (5 min of irradiation). Reduction by 99.99% (30 min of irradiation). |
Le guern et al. 2017 [21] | In vitro | Polymyxin B | 20 h | 420 nm | Porphyrin | S. aureus E. coli P. aeruginosa | Suspension | ND | Antibactericidal activity of the PS and peptide association on 3 strains. |
De Freitas et al. 2018 [12] | In vitro | Aurein 1.2 (AU) | ND | 660 nm | Methylene blue Chlorin e6 | S. aureus A. baumannii E. coli Enterococcus faecium | Suspension | 9 | S. aureus reduction
A. baumannii reduction
E. coli reduction
E. faecium reduction
|
Le guern et al. 2018 [22] | In vitro | Polymyxin B modified by lysine | 20 h | 420 nm | Porphyrin | S. aureus E. coli P. aeruginosa | Suspension | ND | Reduced antibacterial activity of polymyxin modified by lysine. |
Nakonieczana et al. 2018 [23] | In vitro | CAMEL Pexiganan | 668 s 1335 s 2668 s | 514 nm | Rose-bengal (RB) | P. aeruginosa | Suspension | 3 | Reduction by 2.06 log10 CFU/mL for RB + CAM. Reduction by 6.00 log10 CFU/mL for RB + PEX. |
Gao et al. 2019 [24] | In vitro | Magainin I | 2 min 4 min 8 min | 660 nm | Magainin I + Chlorin e6 | P. aeruginosa S. aureus (methicillin resistant) | Biofilm | ND | P. aeruginosa 2 min (0.385 log10 CFU/mL reduction) 4 min (1.645 log10 CFU/mL reduction) 8 min (6.724 log10 CFU/mL reduction) S. aureus 2 min (0.922 log10 CFU/mL reduction) 4 min (3.796 log10 CFU/mL reduction) 8 min (6.586 log10 CFU/mL reduction) |
De Freitas et al. 2019 [13] | In vitro | AU (GLFDIIKKIAESF-NH2) (AU)2K[(GLFDIIKKIAESF)2-k] | ND | 664 nm | Methylene blue Chlorin e6 | Enterococcus faecalis S. aureus E. faecium | Biofilm | 9 | Reducing the early biofilm stage
|
Feese et al. 2019 [25 | In vitro | Alkyne 1-Zn TMPYP | 5, 15, and 30 min | 400 to 700 nm | Porphyrin | Mycobacterium smegmatis | Suspension | Inactivation of 4 Log10 CFU/mL when associated with porphyrin and 1-Zn. | |
Zhang et al. 2019 [26] | In vitro | (KLAKLAK)2(KLA) | 5 min (in vivo) 10 min (in vitro) | 660 nm | PpIX PPK = PpIX + (KLAKLAK)2(KLA) | S. aureus E. coli | Suspension | ND | Inhibition rate S. aureus = 100% for both PS E. coli = 100% (PPK)/50% (PpIX) |
Chu et al. 2021 [27] | In vitro | Bacitracin | 5 and 30 min | 610 nm | Phthalocyanine | E. coli S. aureus | Suspension | 9 | High phototoxicity of the Peptide with PS. The group without light 99% reduced. |
Gao et al. 2021 [28] | In vitro/in vivo | PEGylated polypeptide | 5 min | 660 nm | PEGylated polypeptide + Chlorin e6 | P. aeruginosa | Biofilm | ND | Total eradication of P. aeruginosa biofilms. |
Judzewitsch et al. 2021 [29] | In vitro | ZnTTP-AC | 30 min | Green-light irradiation | ZnTTP-AC | S. aureus P. aeruginosa | Suspension | 3 | 4.5 log10 CFU/mL reduction for S. aureus. Total reduction for P. aeruginosa. |
Qiu et al. 2021 [a] [30] | In vitro/in vivo | GKRWWKWWR-RPLGVRG | 5 min | 660 nm | GKRWWKWWR-RPLGVRG + Chlorin e6 | S. aureus E. coli | Suspension | 3 | Total reduction for S. aureus 90% reduction for E. coli |
Qiu et al. 2021 [b] [31] | In vitro/in vivo | GKRWWKWWRR | 10 min 20 min 30 min | 660 nm | GKRWWKWWRR + Chlorin e6 + AuNPs | S. aureus E. coli | Biofilm | 3 | S. aureus 10 min (~50% viability) 20 min (~20% viability) 30 min (~2.5% viability) E. coli 10 min (~60% viability) 20 min (~42.5% viability) 30 min (~10% viability) |
Studies/Questions | Was the Dose or Exposure Level Administered Adequately Randomized? | Was the Allocation to Study Groups Adequately Concealed? | Were the Experimental Conditions Identical Across Study Groups? | Were Research Personnel Blind to the Study Group During the Study? | Were the Outcome Data Complete without Attrition or Exclusion from the Analysis? | Is the Exposure Characterization Reliable? | Is the Outcome Assessment (Including Blinding of Assessors) Reliable? | Were There No Other Potential Threats to Internal Validity? |
---|---|---|---|---|---|---|---|---|
Bourré et al. 2010 [14] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Yang et al. 2011 [15] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Liu et al. 2012 [16] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Dosseli et al. 2013 [17] | ++ | ++ | ++ | -- | -- | ++ | -- | -- |
Johnson et al. 2013 [18] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Dosseli et al. 2014 [19] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Johnson et al. 2014 [20] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Le Guern et al. 2017 [21] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
De Freitas et al. 2018 [12] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Le Guern et al. 2018 [22] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Nakonieczana et al. 2018 [23] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Gao et al. 2019 [24] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
De Freitas et al. 2019 [13] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Fesse et al. 2019 [25] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Zhang et al. 2019 [26] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Chu et al. 2021 [27] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Gao et al. 2021 [28] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Judzewitsch et al. 2021 [29] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Qiu et al. 2021a [30] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
Qiu et al. 2021b [31] | ++ | ++ | ++ | -- | ++ | ++ | -- | -- |
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Dias, L.M.; Ferrisse, T.M.; Medeiros, K.S.; Cilli, E.M.; Pavarina, A.C. Use of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2022, 23, 3226. https://doi.org/10.3390/ijms23063226
Dias LM, Ferrisse TM, Medeiros KS, Cilli EM, Pavarina AC. Use of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2022; 23(6):3226. https://doi.org/10.3390/ijms23063226
Chicago/Turabian StyleDias, Luana Mendonça, Túlio Morandin Ferrisse, Karine Sousa Medeiros, Eduardo Maffud Cilli, and Ana Claudia Pavarina. 2022. "Use of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 23, no. 6: 3226. https://doi.org/10.3390/ijms23063226