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Article

Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles

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Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland
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Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gen. Hallera 107, 80-416 Gdansk, Poland
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Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
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Department of Radiobiology and Radiation Protection, Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, Poland
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Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warszawa, Poland
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Institute of Advanced Materials and Technologies, National Research University of Electronic Technology, Bld. 1, Shokin Square, Zelenograd, 124498 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Claudiu T. Supuran
Int. J. Mol. Sci. 2022, 23(6), 2980; https://doi.org/10.3390/ijms23062980
Received: 14 December 2021 / Revised: 28 February 2022 / Accepted: 7 March 2022 / Published: 10 March 2022
(This article belongs to the Special Issue Metal Ions in Cancer)
A novel biologically active organic ligand L (N’-benzylidenepyrazine-2-carbohydrazonamide) and its three coordination compounds have been synthesized and structurally described. Their physicochemical and biological properties have been thoroughly studied. Cu(II), Zn(II), and Cd(II) complexes have been analyzed by F-AAS spectrometry and elemental analysis. The way of metal–ligand coordination was discussed based on FTIR spectroscopy and UV-VIS-NIR spectrophotometry. The thermal behavior of investigated compounds was studied in the temperature range 25–800 °C. All compounds are stable at room temperature. The complexes decompose in several stages. Magnetic studies revealed strong antiferromagnetic interaction. Their cytotoxic activity against A549 lung cancer cells have been studied with promising results. We have also investigated the biological effect of coating studied complexes with silver nanoparticles. The morphology of the surface was studied using SEM imaging. View Full-Text
Keywords: antitumor activity; A549 lung cancer cells; coordination compound; FTIR spectroscopy; UV-VIS-NIR spectrophotometry; TG-DTG analysis; magnetization measurements antitumor activity; A549 lung cancer cells; coordination compound; FTIR spectroscopy; UV-VIS-NIR spectrophotometry; TG-DTG analysis; magnetization measurements
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MDPI and ACS Style

Czylkowska, A.; Rogalewicz, B.; Szczesio, M.; Raducka, A.; Gobis, K.; Szymański, P.; Czarnecka, K.; Camargo, B.C.; Szczytko, J.; Babich, A.; Dubkov, S.; Lazarenko, P. Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles. Int. J. Mol. Sci. 2022, 23, 2980. https://doi.org/10.3390/ijms23062980

AMA Style

Czylkowska A, Rogalewicz B, Szczesio M, Raducka A, Gobis K, Szymański P, Czarnecka K, Camargo BC, Szczytko J, Babich A, Dubkov S, Lazarenko P. Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles. International Journal of Molecular Sciences. 2022; 23(6):2980. https://doi.org/10.3390/ijms23062980

Chicago/Turabian Style

Czylkowska, Agnieszka, Bartłomiej Rogalewicz, Małgorzata Szczesio, Anita Raducka, Katarzyna Gobis, Paweł Szymański, Kamila Czarnecka, Bruno Cury Camargo, Jacek Szczytko, Alexey Babich, Sergey Dubkov, and Petr Lazarenko. 2022. "Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles" International Journal of Molecular Sciences 23, no. 6: 2980. https://doi.org/10.3390/ijms23062980

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