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Article

Antioxidative and Anti-Inflammatory Activities of Chrysin and Naringenin in a Drug-Induced Bone Loss Model in Rats

1
Division of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, Croatia
2
Polyclinic Bagatin, Grada Vukovara 269a/10, 10000 Zagreb, Croatia
3
Department of Orthopaedic Surgery, Specialty Hospital St. Catherine, 49210 Zabok, Croatia
4
Division of Molecular Medicine, Laboratory for Protein Dynamics, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
5
Department of Gynaecology and Obstetrics, General Hospital Zabok, 49210 Zabok, Croatia
*
Author to whom correspondence should be addressed.
Academic Editors: Seon-Yong Jeong and Eunkuk Park
Int. J. Mol. Sci. 2022, 23(5), 2872; https://doi.org/10.3390/ijms23052872
Received: 7 February 2022 / Revised: 3 March 2022 / Accepted: 4 March 2022 / Published: 6 March 2022
(This article belongs to the Special Issue The Role of Natural Compounds in Osteoblastic and Osteoclastic Cells)
Oxidative stress (OS) mediators, together with the inflammatory processes, are considered as threatening factors for bone health. The aim of this study was to investigate effects of flavonoids naringenin and chrysin on OS, inflammation, and bone degradation in retinoic acid (13cRA)-induced secondary osteoporosis (OP) in rats. We analysed changes in body and uterine weight, biochemical bone parameters (bone mineral density (BMD), bone mineral content (BMC), markers of bone turnover), bone geometry parameters, bone histology, OS parameters, biochemical and haematological parameters, and levels of inflammatory cytokines. Osteoporotic rats had reduced bone Ca and P levels, BMD, BMC, and expression of markers of bone turnover, and increased values of serum enzymes alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). Malondialdehyde (MDA) production in liver, kidney, and ovary was increased, while the glutathione (GSH) content and activities of antioxidant enzymes were reduced and accompanied with the enhanced release of inflammatory mediators TNF-α, IL-1β, IL-6, and RANTES chemokine (regulated on activation normal T cell expressed and secreted) in serum. Treatment with chrysin or naringenin improved bone quality, reduced bone resorption, and bone mineral deposition, although with a lower efficacy compared with alendronate. However, flavonoids exhibited more pronounced antioxidative, anti-inflammatory and phytoestrogenic activities, indicating their great potential in attenuating bone loss and prevention of OP. View Full-Text
Keywords: oxidative stress; drug-induced osteoporosis; cellular antioxidative and anti-inflammatory response; chrysin; naringenin; rat model of osteoporosis oxidative stress; drug-induced osteoporosis; cellular antioxidative and anti-inflammatory response; chrysin; naringenin; rat model of osteoporosis
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MDPI and ACS Style

Oršolić, N.; Nemrava, J.; Jeleč, Ž.; Kukolj, M.; Odeh, D.; Jakopović, B.; Jazvinšćak Jembrek, M.; Bagatin, T.; Fureš, R.; Bagatin, D. Antioxidative and Anti-Inflammatory Activities of Chrysin and Naringenin in a Drug-Induced Bone Loss Model in Rats. Int. J. Mol. Sci. 2022, 23, 2872. https://doi.org/10.3390/ijms23052872

AMA Style

Oršolić N, Nemrava J, Jeleč Ž, Kukolj M, Odeh D, Jakopović B, Jazvinšćak Jembrek M, Bagatin T, Fureš R, Bagatin D. Antioxidative and Anti-Inflammatory Activities of Chrysin and Naringenin in a Drug-Induced Bone Loss Model in Rats. International Journal of Molecular Sciences. 2022; 23(5):2872. https://doi.org/10.3390/ijms23052872

Chicago/Turabian Style

Oršolić, Nada, Johann Nemrava, Željko Jeleč, Marina Kukolj, Dyana Odeh, Boris Jakopović, Maja Jazvinšćak Jembrek, Tomica Bagatin, Rajko Fureš, and Dinko Bagatin. 2022. "Antioxidative and Anti-Inflammatory Activities of Chrysin and Naringenin in a Drug-Induced Bone Loss Model in Rats" International Journal of Molecular Sciences 23, no. 5: 2872. https://doi.org/10.3390/ijms23052872

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