The Biological Function of MicroRNAs in Bone Tumors
Abstract
:1. Introduction
2. Biogenesis and Biological Function of miRNAs
3. Role of miRNAs in Osteogenesis and Bone Homeostasis
4. Relationship between miRNAs and Cancers: Focus on Bone Tumors
MicroRNA | Prevalent Tumor | Target Gene | Function | References |
---|---|---|---|---|
miR-21 | OS; ES; | PTEN, TPM1, PDCD4 | Increases proliferation | [63,64] |
miR-34 | OS; ES; | P53; Notch | Inhibits proliferation | [65,66] |
Let-7a | OS; ES; | HMGA2; E2F2 | Reduces growth | [67,68,74] |
miR-106 | OS; ES; | PTEN; CDKN1A; | Increases proliferation | [45] |
miR-125b | OS; ES; | P53; Bak; STAT3 | Inhibits proliferation | [75] |
miR-143 | OS; ES; | FOSL2; TFF3; | Inhibits proliferation | [72] |
miR-100 | CS; | mTOR; IGFIR; | Inhibits proliferation | [76] |
miR-16 | OS; | RAB23; SMAD3; | Inhibits proliferation | [77] |
miR-30a | CS; | SOX4; Notch1; | Reduces proliferation | [59] |
miR-181a | CS; | RGS16; RASSF1A; | Increases proliferation | [78] |
miR-19a | OS; | SOCS6; PTEN; | Increases proliferation | [79] |
miR-199a | OS; | PIAS3, Smad1 | Reduces proliferation | [59] |
miR-145 | CS; OS; | SOX9; MMP16 | Inhibits invasion | [58] |
miR-140 | OS; CS; | HDAC4; p21; | Reduces proliferation | [57] |
miR-208a | OS; | PDCD4; ERK1/2; | Increases proliferation | [73] |
miR-221 | OS; | PTEN; | Increases proliferation | [70] |
miR-22 | OS; | ACLY, TWIST1; | Reduces proliferation | [52] |
miR-101 | OS; | ROCK1; EZH2/Wnt/β-Catenin | Reduces proliferation and invasion | [53] |
miR-483 | OS; | STAT3 | Increases proliferation | [54] |
miR-191 | OS, | BDNF; CDK6; | Increases proliferation | [80] |
miR-99a | OS; | TNFAIP8 | Reduces proliferation | [61] |
miR-27a | OS | TET1 | Increases proliferation | [60] |
miR-424 | OS; | CcnA2 | Reduces proliferation | [62] |
miR-449a | OS; | CcnA2 | Reduces proliferation | [62] |
miR-30c | OS; | MEF2D | Reduces proliferation | [59] |
miR-206 | OS; | HDAC4 | Increases proliferation | [58] |
miR-665 | OS, | Rab23 | Reduces metastasis and invasion | [81] |
miR-15a | OS; | Bcl2 | Reduces metastasis and invasion | [82] |
miR-17-5p | OS; | BRCC2 | Increases proliferation | [83] |
miR-590-5p | OS; | KLF5 | Reduces proliferation | [84] |
miR-212 | OS; | SOX4 | Reduces proliferation | [85] |
miR-132 | OS; | SOX4 | Reduces proliferation | [86] |
miR-23b | OS; | PI3K/AKT | Increases proliferation | [87] |
miR-183 | OS; | Ezrin | Reduces metastasis | [88] |
4.1. Role of miRNAs in Osteosarcoma
4.2. Role of miRNAs in Ewing’s Sarcoma
4.3. Role of miRNAs in Chondrosarcoma
5. miRNAs as Diagnostic and Predictive Biomarkers in Bone Tumors
6. Conclusions
7. Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Osteosarcoma | Chondrosarcoma | Ewing’s Sarcoma |
---|---|---|
miRNA-21 | miRNA-21 | miRNA-21 |
miRNA-106 | miRNA-181 | miRNA-106 |
miRNA-181a | miRNA-143 | miRNA-19a |
miRNA-16 | miRNA-34 | miRNA-30a |
miRNA-34 | miRNA-145 | miRNA-143 |
miRNA-100 | miRNA-221 | miRNA-22 |
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Scuderi, S.A.; Calabrese, G.; Paterniti, I.; Campolo, M.; Lanza, M.; Capra, A.P.; Pantaleo, L.; Munaò, S.; Colarossi, L.; Forte, S.; et al. The Biological Function of MicroRNAs in Bone Tumors. Int. J. Mol. Sci. 2022, 23, 2348. https://doi.org/10.3390/ijms23042348
Scuderi SA, Calabrese G, Paterniti I, Campolo M, Lanza M, Capra AP, Pantaleo L, Munaò S, Colarossi L, Forte S, et al. The Biological Function of MicroRNAs in Bone Tumors. International Journal of Molecular Sciences. 2022; 23(4):2348. https://doi.org/10.3390/ijms23042348
Chicago/Turabian StyleScuderi, Sarah Adriana, Giovanna Calabrese, Irene Paterniti, Michela Campolo, Marika Lanza, Anna Paola Capra, Luca Pantaleo, Stefania Munaò, Lorenzo Colarossi, Stefano Forte, and et al. 2022. "The Biological Function of MicroRNAs in Bone Tumors" International Journal of Molecular Sciences 23, no. 4: 2348. https://doi.org/10.3390/ijms23042348