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Review

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s Disease

1
Diabetic Neuropathy Project, Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo 156-8506, Japan
2
Department of Neurotherapeutics, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
3
Department of Neurology, Faculty of Medicine, Kindai University, Osaka-Sayama 589-8511, Japan
*
Authors to whom correspondence should be addressed.
Academic Editors: Kurt A. Jellinger, Masamitsu Yamaguchi and Shinya Yamamoto
Int. J. Mol. Sci. 2022, 23(3), 1519; https://doi.org/10.3390/ijms23031519
Received: 29 December 2021 / Revised: 24 January 2022 / Accepted: 26 January 2022 / Published: 28 January 2022
(This article belongs to the Special Issue Role of Drosophila in Human Disease Research 2.0)
α-Synuclein (αSyn) plays a major role in the pathogenesis of Parkinson’s disease (PD), which is the second most common neurodegenerative disease after Alzheimer’s disease. The accumulation of αSyn is a pathological hallmark of PD, and mutations in the SNCA gene encoding αSyn cause familial forms of PD. Moreover, the ectopic expression of αSyn has been demonstrated to mimic several key aspects of PD in experimental model systems. Among the various model systems, Drosophila melanogaster has several advantages for modeling human neurodegenerative diseases. Drosophila has a well-defined nervous system, and numerous tools have been established for its genetic analyses. The rapid generation cycle and short lifespan of Drosophila renders them suitable for high-throughput analyses. PD model flies expressing αSyn have contributed to our understanding of the roles of various disease-associated factors, including genetic and nongenetic factors, in the pathogenesis of PD. In this review, we summarize the molecular pathomechanisms revealed to date using αSyn-expressing Drosophila models of PD, and discuss the possibilities of using these models to demonstrate the biological significance of disease-associated factors. View Full-Text
Keywords: Drosophila; α-Synuclein; Parkinson’s disease Drosophila; α-Synuclein; Parkinson’s disease
MDPI and ACS Style

Suzuki, M.; Sango, K.; Nagai, Y. Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s Disease. Int. J. Mol. Sci. 2022, 23, 1519. https://doi.org/10.3390/ijms23031519

AMA Style

Suzuki M, Sango K, Nagai Y. Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s Disease. International Journal of Molecular Sciences. 2022; 23(3):1519. https://doi.org/10.3390/ijms23031519

Chicago/Turabian Style

Suzuki, Mari, Kazunori Sango, and Yoshitaka Nagai. 2022. "Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson’s Disease" International Journal of Molecular Sciences 23, no. 3: 1519. https://doi.org/10.3390/ijms23031519

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