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Article

Floating Ricobendazole Delivery Systems: A 3D Printing Method by Co-Extrusion of Sodium Alginate and Calcium Chloride

1
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
2
PhD Program in Drug Discovery and Development, University of Salerno (SA), 84081 Fisciano, Italy
3
Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET, Córdoba X5000HUA, Argentina
4
Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba X5000HUA, Argentina
5
Department of Industrial Engineering, University of Salerno, 84081 Fisciano, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Barbara Zavan, Stefano Sivolella and Alfredo Ronca
Int. J. Mol. Sci. 2022, 23(3), 1280; https://doi.org/10.3390/ijms23031280
Received: 20 December 2021 / Revised: 19 January 2022 / Accepted: 20 January 2022 / Published: 24 January 2022
(This article belongs to the Special Issue 3D Printing and Biomaterials for Biological and Medical Application)
At present, the use of benzimidazole drugs in veterinary medicine is strongly limited by both pharmacokinetics and formulative issues. In this research, the possibility of applying an innovative semi-solid extrusion 3D printing process in a co-axial configuration was speculated, with the aim of producing a new gastro-retentive dosage form loaded with ricobendazole. To obtain the drug delivery system (DDS), the ionotropic gelation of alginate in combination with a divalent cation during the extrusion was exploited. Two feeds were optimized in accordance with the printing requirements and the drug chemical properties: the crosslinking ink, i.e., a water ethanol mixture containing CaCl2 at two different ratios 0.05 M and 0.1 M, hydroxyethyl cellulose 2% w/v, Tween 85 0.1% v/v and Ricobendazole 5% w/v; and alginate ink, i.e., a sodium alginate solution at 6% w/v. The characterization of the dried DDS obtained from the extrusion of gels containing different amounts of calcium chloride showed a limited effect on the ink extrudability of the crosslinking agent, which on the contrary strongly influenced the final properties of the DDS, with a difference in the polymeric matrix toughness and resulting effects on floating time and drug release. View Full-Text
Keywords: semi-solid extrusion 3D printing; alginate ionotropic gelation; floating DDS semi-solid extrusion 3D printing; alginate ionotropic gelation; floating DDS
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MDPI and ACS Style

Falcone, G.; Real, J.P.; Palma, S.D.; Aquino, R.P.; Del Gaudio, P.; Garofalo, E.; Russo, P. Floating Ricobendazole Delivery Systems: A 3D Printing Method by Co-Extrusion of Sodium Alginate and Calcium Chloride. Int. J. Mol. Sci. 2022, 23, 1280. https://doi.org/10.3390/ijms23031280

AMA Style

Falcone G, Real JP, Palma SD, Aquino RP, Del Gaudio P, Garofalo E, Russo P. Floating Ricobendazole Delivery Systems: A 3D Printing Method by Co-Extrusion of Sodium Alginate and Calcium Chloride. International Journal of Molecular Sciences. 2022; 23(3):1280. https://doi.org/10.3390/ijms23031280

Chicago/Turabian Style

Falcone, Giovanni, Juan P. Real, Santiago D. Palma, Rita P. Aquino, Pasquale Del Gaudio, Emilia Garofalo, and Paola Russo. 2022. "Floating Ricobendazole Delivery Systems: A 3D Printing Method by Co-Extrusion of Sodium Alginate and Calcium Chloride" International Journal of Molecular Sciences 23, no. 3: 1280. https://doi.org/10.3390/ijms23031280

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