Plastid Transformation: New Challenges in the Circular Economy Era
Abstract
:1. Introduction
2. Plastid Transformation Technology
3. New Advances in Plastid Expression of Recombinant Proteins
4. Plastid-Based Enzymes for the Biorefinery Industry
Heterologous Protein | Gene | Source | Expression Level | Phenotype of Transplastomic Plants | Physico-Chemical Characterization | References |
---|---|---|---|---|---|---|
acetyl xylan esterase | axe1 | Trichoderma reesei | color change observed | wild type | - | [30] |
β-glucosidase | bgl1 | Trichoderma reesei | 14 U/mg CTSP a | wild type | 50 °C, pH 5.2 b | [30] |
β-glucosidase | bglC1 | Thermobifida fusca | 5–40% TSP c | mutant | Topt 45 °C, pHopt 7.0 | [33] |
β-glucosidase | bglC | Thermobifida fusca | up to 12% TSP | nd d | 50 °C b | [34] |
β-glucosidase | celB | Pyrococcus furiosus | up to 75% TSP | wild type | Topt 105 °C, pH 4.0–5.0 | [12] |
β-glucosidase | bgl1 | Aspergillus niger | 20 mg/g TSP | wild type | Topt 40 °C, pH 5.0 | [35] |
β-mannase | man1 | Trichoderma reesei | 25 U/g FW | mutant (pale green) | 40 °C < Topt < 70 °C, 3.0 < pHopt < 7.0 | [36] |
cellulases | celA | Thermotoga neapolitana | 23 mg/g TSP | wild type | Topt 65 °C, pH 5.0 | [35] |
cellulases | celB | Thermotoga neapolitana | 21 mg/g TSP | wild type | Topt 65 °C, pH 5.0 | [35] |
cutinase | cut | Fusarium solani | 15 U/mg CTSP | wild type | 30 °C, pH 8.0 b | [30] |
cutinase | cut | Trichoderma reesei | nd | mutant | nd | [37] |
endo-1,4-β-glucanase | cel6A | Thermobifida fusca | up to 2% TSP | nd b | 50 °C b | [38] |
endoglucanase | cel6A | Thermobifida fusca | up to 10% TSP | wild type | nd | [39] |
endo-β-glucanase E1 catalytic domain (E1cd) | e1cd | Acidothermus cellulolyticus | 12% TSP | mutant | 55 °C b | [40] |
endoglucanase | celD | Clostridium thermocellum | up to 4930 U/g FW | wild type | Topt 60 °C, pHopt 6.0 | [30] |
endoglucanase | egI | Trichoderma reesei | 339 U/mg CTSP | wild type | 50 °C, pH 5.2 b | [30] |
endoglucanase | cel9A | Thermobifida fusca | 40% TSP | mutant | nd | [33] |
endoglucanase | egph | Pyrococcus horikoshii | 25% TSP | mutant (pale green) | 85 °C, pH 5.5 b | [41] |
endoglucanase | cel7, endoV, celK1 | Chaetomium globosum, Paenibacillus sp. | 8–10% TPC e | nd | 60 °C b | [42,43] |
endoglucanase | endo | Sulfolobus solfataricus | 2% TSP | mutant (severe retarded growth) | nd | [12] |
exo-cellobiohydrolase | cel6B | Thermobifida fusca | 3% TSP | nd b | 50 °C b | [38] |
exo-cellobiohydrolase | cel3 | Phanerochaete chrysosporium | 0.4 U/mg protein | nd | nd | [42,43] |
exoglucanase | celO | Clostridium thermocellum | 442 U/mg CTSP | wild type | 60 °C, pH 5.2 b | [30] |
exoglucanase | cel6B | Thermobifida fusca | 5% TSP | mutant | nd | [33] |
exoglucanase | cel6 | Chaetomium globosum | 0.4 U/mg protein | nd | nd | [42,43] |
lipase | lipY | Mycobacterium tuberculosis | nd | wild type | - | [30] |
manganese peroxidase | mnP-2 | Phanerochaete chrysosporium | nd | normal (high growth rate) | 65 °C, pH 6.0 | [44] |
pectate lyases | pelA, pelB, pelD | Fusarium solani | up to 32 U/g FW | wild type | Topt 40 °C, 6.0 > pHopt > 8.0 | [30] |
pectinase | pelA | Streptomyces thermocarboxydus | nd | wild type | 60 °C, pH 7.0 | [44] |
swollenin | swo1 | Trichoderma reesei | swelling observed | wild type | - | [30] |
swollenin | swo1 | Trichoderma reesei | nd | mutant | nd | [37] |
xylanase | xynA | Bacillus subtilis strain NG-27 | 6% TSP | wild type | Topt 70 °C pHopt 8.4 | [29] |
xylanase | xyn2 | Trichoderma reesei | 421 U/mg CTSP | wild type | 50 °C, pH 5.2 cb | [30] |
xylanase | xyl10B | Thermotoga maritima | up to 15% TSP | wild type | termostable at 85 °C for 30 min | [31] |
xylanase | xynA | Clostridium cellulovorans | 0.5% TSP | wild type | 40 °C b | [32] |
xylanase | xyn10A | Aspergillus niger | up to 3% TSP | wild type | 40 °C b | [32] |
xylanase | xyn11B | Aspergillus niger | up to 6% TSP | wild type | 40 °C b | [32] |
xylanase | xyn | Alicyclobacillus acidocaldarius | 36% TSP | wild type | Topt 80 °C pH 6.0 | [12] |
xyloglucanase | xeg74 | Thermobifida fusca | 5–40% TSP | mutant (pigment deficiency, retarded growth) | nd | [33] |
5. New Challenges for Biocatalysts and the Circular Economy
5.1. Enzymes for Lignocellulosic Waste Biorefinery
5.1.1. Lytic Polysaccharide Monooxygenases
5.1.2. Arabinofuranosidases
5.1.3. α-Glucuronidases
5.1.4. Feruloyl Esterases
5.1.5. Glucuronoyl Esterases
5.2. Other Enzymes for Waste Biorefinery
5.2.1. Chitinases
5.2.2. Chitin Deacetylase
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Plastid Transformation Method | Strengths | Weaknesses | Reference |
---|---|---|---|
Linear DNA fragments | No vector construction required | Sequencing of linear fragments required | [25] |
Minichromosome | Stable and efficient amplification of foreign DNA | Need to use transplastomic plants expressing the Rep protein as plant host | [27] |
Fusion peptide KH-AtOEP34 | Reduction of time-consuming steps | No homoplasmic plants obtained | |
Applicable to recalcitrant crops (rice, kenaf) | Low transformation efficiency | [28] | |
Possible integration of exogenous DNA onto nuclear DNA |
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Tamburino, R.; Marcolongo, L.; Sannino, L.; Ionata, E.; Scotti, N. Plastid Transformation: New Challenges in the Circular Economy Era. Int. J. Mol. Sci. 2022, 23, 15254. https://doi.org/10.3390/ijms232315254
Tamburino R, Marcolongo L, Sannino L, Ionata E, Scotti N. Plastid Transformation: New Challenges in the Circular Economy Era. International Journal of Molecular Sciences. 2022; 23(23):15254. https://doi.org/10.3390/ijms232315254
Chicago/Turabian StyleTamburino, Rachele, Loredana Marcolongo, Lorenza Sannino, Elena Ionata, and Nunzia Scotti. 2022. "Plastid Transformation: New Challenges in the Circular Economy Era" International Journal of Molecular Sciences 23, no. 23: 15254. https://doi.org/10.3390/ijms232315254