Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis
Abstract
:1. Introduction
2. Results
2.1. Brain-Derived Neurotrophic Factor
2.2. Signaling Pathway of BDNF
2.3. Role of Gut Microbiota in Depression
2.3.1. Gut Microbiota–Brain Axis in Depression
2.3.2. Role of BDNF in Irritable Bowel Syndrome Induced Depression
2.3.3. Findings Related to Gut Microbiota in Patients with Depression
2.4. Role of BDNF-mTORC1 Signaling Pathway in Depression
2.5. Effects of Antidepressants on BDNF and Their Related Side Effects
2.6. Modulation of BDNF Signaling by Different Natural Products and Their Derivatives
2.6.1. Flavonoids, Flavanones, and Flavanol
Apigenin
Baicalein
Hesperidin
Luteolin-7-O-glucuronide
Naringenin
Quercetin
Sanggenon G
Silibinin
Orange Juice
2.6.2. Phenol, Polyphenol, and Phenolic Acid Derivatives
Chlorogenic Acid
Curcumin
Ellagic Acid
Epigallocatechin-3-gallate
Eleutheroside E
Eugenol
Resveratrol
Thymol
2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside
2.6.3. Fatty Acids, Lignan, Steroids, and Terpenoids
Ginsenoside Rd
Limonene
Omega-3 Fatty Acids
Oleanolic Acid
Poria cocos
Sesamol
2.6.4. Anthraquinone and Anthocyanin
Cyandin-3-glucoside and Cyanidin-3-sophoroside-5-glucoside
Hypericin
2.6.5. Carotenoids
Fucoxanthin
Lycopene
2.6.6. Bodily Fluids
Nicotinamide Riboside
Honey
2.6.7. Medicinal Plants and Herbal Formulations
Cinnamomum zeylanicum
Dendrobium officinale
Huanglian-Jie-Du-Tang
Cocos nucifera Husk Fiber
Semen Sojae Praeparatum
2.6.8. Phthalide
3-n-Butylphthalide
2.6.9. Probiotics
Clostridium butyricum (C. butyricum)
Porphyromonas gingivalis
Bifidobacterium longum NCC3001
Lactobacillus casei (L. casei)
Lactobacillus helveticus R0052
Lactobacillus plantarum
Lactobacillus rhamnosus zz-1
3. Discussion
4. Materials and Methods
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Natural Products | Sources | Targeted Pathway | Model | Pharmacological Action | References |
---|---|---|---|---|---|
Cyandin-3-glucoside and cyanidin-3-sophoroside-5-glucoside | Cauliflower (Brassica oleraceavar. Botrytis L.) | ERK/CREB/ BDNF | Pathogen-free female mice (4 weeks old) | Upregulates BDNF, which also promotes neurogenesis and dendrite development in hippocampus | [181] |
Apigenin | Fruits and vegetables | CREB/BDNF | Male Swiss albino mice (12 weeks old) | Prevents cognitive deficit and CREB-BDNF upregulation in the hippocampus | [78] |
Baicalein | Scutellaria baicalensis Georgi | BDNF/TrkB/ CREB | Male C57BL/6J mice (8 weeks old) | Synaptic function protection and neuroprotection against inflammation and depression | [89,90] |
3-n-Butylphthalide | Chinese celery | BDNF/ERK/ mTOR and serotonergic | Male Sprague–Dawley (SD; 6 weeks old) | Restores the levels of BDNF, p-ERK, and mTOR | [165] |
Chlorogenic acid | Coffee beans | BDNF/TrkB | Male SD rats (6 weeks old) | Induces anxiolytic behavior, modulates autonomic regulation, and activates hippocampal BDNF signaling | [108] |
Cinnamon | Cinnamomum zeylanicum | BDNF/TrkB | Thirty-two male Wistar rats | Antidepressant | [157] |
Curcumin | Curcuma longa | BDNF/ERK | Adult male Wistar (6 weeks old) | Antidepressant | [110,111,112] |
Alcohol-soluble polysaccharides | Dendrobium officinale | BDNF/TrkB/ CREB | Male ICR mice (6 weeks old) and SD rats (6 weeks old) | Antidepressant-like effect by regulating the gut–brain axis. | [159] |
Ellagic acid | Punica granatum | BDNF and serotoninergic | Male C57BL/6 mice (6 weeks old) | Antidepressant | [114,115] |
Epigallocatechin-3-gallate | Green tea (Camellia sinensis) | BDNF, Akt, monoaminergic | Female SD rats (6 weeks old), male C57BL/6J mice | Modulates mood, mitigates anxiety, and improves postmenopausal depression | [116,117] |
Eleutheroside E | Acanthopanax senticosus HARM | PKA/CREB/ BDNF, CREB/BDNF | Male SD rats (6 weeks old) | Antidepressant and regulates autonomic function | [119,120] |
Eugenol | Rhizoma acori graminei | BDNF | Fifty male ddy mice (6 weeks old) | Antidepressant | [182] |
Fucoxanthin | PKA/cAMP, CREB | BV-2 cells | Ameliorates neurodegenerative diseases | [149] | |
Ginsenoside Rg2 | Panax ginseng | BDNF/TrkB | Adult male C57BL/6J mice (8 weeks old) | Mitigates anxiety/depression and colitis | [129,130] |
Hesperidin | Citrus fruits | BDNF/TrkB | ICR male mice (6–8 weeks old), male NMRI mice (10–11 weeks old) | Reduces CUMS and depression caused by mild traumatic brain injury | [91,92,183] |
Hypericin | Hypericum triquetrifolium | BDNF | Adult male Wistar rats | Neuroprotection against depression and inflammation | [144,146] |
Limonene | Citrus Sinensis, C. Reticulata | BDNF/TrkB | 155 male Kunming mice at 5 weeks | Antidepressant | [131,132] |
Luteolin-7-O-glucuronide | Perilla frutescens | BDNF/TrkB/ CREB | C57BL/6 male mice (7 weeks old) | Improves depression-like and stress-coping behaviors in sleep deprivation | [94] |
Lycopene | Solanum lycopersicum, Citrullus lanatus | BDNF, gut microbiota | Male C57BL/6 mice (8 weeks old) | Improves DSS-induced depression and anxiety-like behavior | [152,153] |
Mustard leaves | Brassica juncea | BNDF and apoptosis | Male C57BL/6 mice (6 weeks old) | Reduces stress and depression | [122] |
Naringenin | Grapes (Vitis vinifera) | BDNF | Thirty-five male Swiss mice | Reduces stress and depression | [96,97] |
Nicotinamide riboside | Milk and yeast | gut microbial pathway, BDNF/AKT | Male C57BL/6J mice (7 weeks old) | Alters intestinal microbiota with microglial activation and exhibits antidepressant activity | [143] |
Oleanolic acid | Olea europaea | ERK1/CREB/ BDNF | Male ICR mice (6 weeks old) | Antidepressant | [135,136] |
Omega-3 fatty acids | Fish oil | BDNF/CREB | Male SD rats | Maintains neuronal function and plasticity, improves impaired learning ability after traumatic brain injury, and exhibits antidepressant activity | [134] |
Quercetin | Fruits and vegetables | CREB/BDNF | Male SD rats (8 weeks old) | Antidepressant | [98,99] |
Resveratrol | Polygonum cuspidatum | PKA/CREB/ BDNF | Male adult SD | Exhibits anti-IBS-like effects on depression, anxiety, visceral hypersensitivity, and intestinal motility | [124,125] |
Sanggenon G | Morus alba | BDNF | Male SD rats (8 weeks old) | Antidepressant | [101] |
Sesamol | Sesame oil and seeds (Sesamum indicum L.) | BDNF/TrkB/ CREB | C57BL/6J male mice (8 weeks old) | Prevents IBD and associated symptoms of anxiety and depression | [142] |
Silibinin | Silybum marianum | BDNF/TrkB | Male SD rats (6–8 weeks old), male C57BL/6 mice | Attenuated autophagy and neuroprotection against anxiety and depression | [103,104] |
Triterpenoids | Poria cocos | microbial | Male SD rats | Antidepressant | [138] |
2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside | Polygonum multiflorum | BDNF/TrkB | C57BL/6J mice (6–8 weeks old) | Antidepressant | [128] |
Thymol | T. vulgaris | BDNF | Adult female Swiss mice (8–10 weeks old) | Restores short-term memory and improves depression | [127] |
Orange juice | Gut microbiota and BDNF | Young adults | Reduces depression through gut microbiota modulation | [107] | |
Honey | Tualang honey | BDNF | Female SD rats (8 weeks old) | Exhibits anxiolytic and antidepressant effects | [155] |
Huanglian-Jie-Du-Tang | Coptis chinensis Franch | BDNF/TrkB/ CREB | Male SD rats | Exhibits antidepressant-like effect | [160] |
Husk fiber | Cocos nucifera | BDNF | Male Swiss mice (8 weeks old) | Neuroprotection against oxidative stress and depression | [162] |
Semen Sojae Praeparatum | Mixture of mulberry leaves, lentils, black beans fermented with bacillus sp. DU-106, R. Chinensis 12 | microbial and BDNF | Adult male SD rats | Antidepressant and modulates gut microbiota | [163] |
Probiotic | Bifidobacterium longum NCC3001 | BDNF | Adult patients with a diagnosis of IBS with diarrhea and mild to moderate anxiety and/or depression | Antidepressant and adequate relief of IBS symptoms | [170] |
Probiotic | Clostridium butyricum | BDNF and serotonin | Adult (age 6–8 weeks, 18–22 g) male C57BL/6J mice | Regulates gut microbiota and acts as antidepressant | [166,167] |
Probiotic | Lactobacillus casei | BDNF/ERK, BDNF/TrkB | Pregnant SD female rats | Antidepressant altering gut microbiota composition, brain monoamines, and oxidative stress | [171,172] |
Probiotic | Lactobacillus helveticus R0052 | BDNF | Patients with mild to moderate melancholic depression | Antidepressant | [174] |
Probiotic | Lactobacillus plantarum | BDNF | Male C57BL/6J mice (7 weeks old), male Wistar rats (8–12 weeks old) | Antidepressant, stimulates the gut–brain axis, and can potentially promote brain development and function. | [176,177,178] |
Probiotic | Lactobacillus rhamnosus zz-1 | BDNF/TrkB | Male C57BL/6 mice (4 weeks old) | Antidepressant via regulating the intestinal microenvironment | [180] |
Probiotic | Porphyromonas gingivalis | BDNF | Female C57Bl/6J wild-type mice | Antidepressant | [168] |
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Liaqat, H.; Parveen, A.; Kim, S.-Y. Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis. Int. J. Mol. Sci. 2022, 23, 14968. https://doi.org/10.3390/ijms232314968
Liaqat H, Parveen A, Kim S-Y. Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis. International Journal of Molecular Sciences. 2022; 23(23):14968. https://doi.org/10.3390/ijms232314968
Chicago/Turabian StyleLiaqat, Humna, Amna Parveen, and Sun-Yeou Kim. 2022. "Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis" International Journal of Molecular Sciences 23, no. 23: 14968. https://doi.org/10.3390/ijms232314968