Dual (pH- and ROS-) Responsive Antibacterial MXene-Based Nanocarrier for Drug Delivery
Abstract
:1. Introduction
2. Results and Discussion
2.1. FTIR and Raman Spectra
2.2. Physicochemical Analysis
2.3. Morphology
2.4. XPS Spectra
2.5. In Vitro Antibacterial Activity
2.6. In Vitro Drug Release Profile
2.7. Drug Release Kinetics
3. Materials and Method
3.1. Materials
3.2. Characterization
3.3. Synthesis of MXene Nanosheets
3.4. Synthesis of MXene-NH2 Nanosheets
3.5. Synthesis of 3,3′-Diselanediyldipropionic Acid
3.6. Synthesis of MXene-Se Nanosheets
3.7. Synthesis of MXene-Se-DOX Nanosheets
3.8. Antibacterial Activity
3.9. Loading Capacity and Drug Release Study
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sample | Element At. % | ||||||
---|---|---|---|---|---|---|---|
Ti | C | O | F | N | Si | Se | |
MXene | 7.36 | 28.23 | 12.58 | 50.59 | - | - | - |
MXene-Se | 7.68 | 55.42 | 0.73 | 1.83 | 3.49 | 4.56 | 0.73 |
MXene-Se-DOX | 6.54 | 54.09 | 28.62 | 1.44 | 3.57 | 4.34 | 0.29 |
Sample Code | Release Medium | Korsmeyer–Peppas a | ||
---|---|---|---|---|
n | kp | R2 | ||
pH 5.5 | 0.271 | 2.075 | 0.898 | |
pH 7.4 | 0.096 | 0.713 | 0.937 | |
pH 7.4 + H2O2 | 0.143 | 12.51 | 0.974 | |
MXene-Se-DOX | pH 7.4 + GSH | 0.159 | 15.16 | 0.913 |
pH 5.5 + H2O2 | 0.209 | 26.67 | 0.964 | |
pH 5.5 + GSH | 0.201 | 32.52 | 0.979 |
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Zhang, W.-J.; Li, S.; Yan, Y.-Z.; Park, S.S.; Mohan, A.; Chung, I.; Ahn, S.-k.; Kim, J.R.; Ha, C.-S. Dual (pH- and ROS-) Responsive Antibacterial MXene-Based Nanocarrier for Drug Delivery. Int. J. Mol. Sci. 2022, 23, 14925. https://doi.org/10.3390/ijms232314925
Zhang W-J, Li S, Yan Y-Z, Park SS, Mohan A, Chung I, Ahn S-k, Kim JR, Ha C-S. Dual (pH- and ROS-) Responsive Antibacterial MXene-Based Nanocarrier for Drug Delivery. International Journal of Molecular Sciences. 2022; 23(23):14925. https://doi.org/10.3390/ijms232314925
Chicago/Turabian StyleZhang, Wei-Jin, Shuwei Li, Yong-Zhu Yan, Sung Soo Park, Anandhu Mohan, Ildoo Chung, Suk-kyun Ahn, Jung Rae Kim, and Chang-Sik Ha. 2022. "Dual (pH- and ROS-) Responsive Antibacterial MXene-Based Nanocarrier for Drug Delivery" International Journal of Molecular Sciences 23, no. 23: 14925. https://doi.org/10.3390/ijms232314925