AQP4-MOG Double-Positive Neuromyelitis Optica Spectrum Disorder: Case Report with Central and Peripheral Nervous System Involvement and Review of Literature
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sex | Age | Onset Phenotype | N° Relapses | Current EDSS | Other Antibody | Spine Lesion | Brain Lesion | Treatment | |
---|---|---|---|---|---|---|---|---|---|
Hyun et al., 2017 [6] | M | 32 | LETM | 4 | 7 | Anti-SS-A Ab (+), antinuclear Ab (+), speckled pattern | NA | None | AZA |
Höftberger et al., 2014 [7] | F | 58 | LETM + ON | 1 | 2 | No | C1-C5 | None | RTX |
F | 50 | LETM + ON | 1 | 2 | No | C4-T2 | Aspecific WML | AZA | |
Yan et al., 2016 [8] | F | 15 | LETM + ON | 3 | 7 | No | C4-conus | Large MS-like lesions | CS, AZA |
F | 36 | LETM | 8 | 8 | No | T1-conus | Small MS-like lesions | RTX | |
F | 18 | LETM + ON | 8 | 8.5 | Anti-SS-A A/B, Anti-Tg, anti-TPO | C1-conus | Small MS-like lesions | Met HCQ | |
F | 60 | LETM | 6 | 8.5 | No | C2-conus | Small MS-like lesions | CS, AZA | |
F | 49 | LETM | 3 | 7.5 | No | C1-conus | Small MS-like lesions | CS, AZA | |
F | 33 | ON | 6 | 3 | No | C3-conus | Large MS-like lesions | CS, AZA | |
F | 15 | ON | 7 | 1 | No | C1-conus | ADEM-like | CS, AZA | |
F | 20 | LETM + ON | 10 | 6.5 | No | C1-conus | ADEM-like | CS, AZA | |
F | 30 | LETM | 4 | 7.5 | No | C1-conus | ADEM-like | RTX | |
F | 36 | LETM | 6 | 8 | No | C1-T12 | Small MS-like lesions | RTX | |
Ishikawa et al., 2019 [10] | F | 24 | ON | 3 | NA | NA | NA | NA | CS, Iv Ig, AZA |
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Spiezia, A.L.; Carotenuto, A.; Iovino, A.; Moccia, M.; Gastaldi, M.; Iodice, R.; Tedeschi, E.; Petracca, M.; Lavorgna, L.; d’Ambrosio, A.; et al. AQP4-MOG Double-Positive Neuromyelitis Optica Spectrum Disorder: Case Report with Central and Peripheral Nervous System Involvement and Review of Literature. Int. J. Mol. Sci. 2022, 23, 14559. https://doi.org/10.3390/ijms232314559
Spiezia AL, Carotenuto A, Iovino A, Moccia M, Gastaldi M, Iodice R, Tedeschi E, Petracca M, Lavorgna L, d’Ambrosio A, et al. AQP4-MOG Double-Positive Neuromyelitis Optica Spectrum Disorder: Case Report with Central and Peripheral Nervous System Involvement and Review of Literature. International Journal of Molecular Sciences. 2022; 23(23):14559. https://doi.org/10.3390/ijms232314559
Chicago/Turabian StyleSpiezia, Antonio Luca, Antonio Carotenuto, Aniello Iovino, Marcello Moccia, Matteo Gastaldi, Rosa Iodice, Enrico Tedeschi, Maria Petracca, Luigi Lavorgna, Alessandro d’Ambrosio, and et al. 2022. "AQP4-MOG Double-Positive Neuromyelitis Optica Spectrum Disorder: Case Report with Central and Peripheral Nervous System Involvement and Review of Literature" International Journal of Molecular Sciences 23, no. 23: 14559. https://doi.org/10.3390/ijms232314559