The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity

Round 1

Reviewer 1 Report

This is a comprehensive review article about a role of FXR in various liver disorders, and covers from basic biology to clinical applications. Also, the authors explain present status of progress of clinical trials of OA, a ligand of FXR, as a pharmacological therapy for PBC and NAFLD. The explanation has been made from a quite neutral standpoint, and looks very fair. I believe that it can satisfy many readers of various backgrounds.

Author Response

Dear Reviewer 1

We were happy to see the interest and feedback to our manuscript entitled “The farnesoid X receptor as a master regulator of hepatotoxicity”. We appreciate the comments given to the original submission. Note that in the process of manuscript revision, we adjusted minor parts, which are highlighted in yellow. We hope that the manuscript is now suitable for publication in IJMS.

 

 

 

Reviewer 2 Report

This compelling article discusses the role of the farnesoid X receptor as the true guardian of liver function by multifactorial preserving liver integrity and functionality.

The manuscript is well written, addressing the topic in-depth and with an up-to-date bibliography.

Some aspects that could improve the work would be:

Adding a list of abbreviations.

Sections 2 and 3 have explanatory figures. In Sections 4 and 5, it would be more illustrative if summarized with a graph or a table.

Reference 149 is missing the publication date of the post.

Author Response

"Please see the attachment."

Author Response File: Author Response.docx