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Article

Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner

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Dipartimento di Scienze della Salute, Universitá di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
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APC Microbiome Ireland, University College Cork, T12 YT20 Cork, Ireland
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Department of Anatomy and Neuroscience, University College Cork, T12 YT20 Cork, Ireland
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Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA), Universitá di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
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Laboratoire NutriNeuro, UMR INRAE, Bordeaux INP, Université de Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux, France
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Authors to whom correspondence should be addressed.
Academic Editor: Alain Couvineau
Int. J. Mol. Sci. 2022, 23(2), 862; https://doi.org/10.3390/ijms23020862
Received: 14 December 2021 / Revised: 11 January 2022 / Accepted: 12 January 2022 / Published: 13 January 2022
Exposure to repeated social stress may cause maladaptive emotional reactions that can be reduced by healthy nutritional supplementation. Histaminergic neurotransmission has a central role in orchestrating specific behavioural responses depending on the homeostatic state of a subject, but it remains to be established if it participates in the protective effects against the insults of chronic stress afforded by a healthy diet. By using C57BL/6J male mice that do not synthesize histamine (Hdc−/−) and their wild type (Hdc+/+) congeners we evaluated if the histaminergic system participates in the protective action of a diet enriched with polyunsaturated fatty acids and vitamin A on the deleterious effect of chronic stress. Behavioural tests across domains relevant to cognition and anxiety were performed. Hippocampal synaptic plasticity, cytokine expression, hippocampal fatty acids, oxylipins and microbiota composition were also assessed. Chronic stress induced social avoidance, poor recognition memory, affected hippocampal long-term potentiation, changed the microbiota profile, brain cytokines, fatty acid and oxylipins composition of both Hdc−/− and Hdc+/+ mice. Dietary enrichment counteracted stress-induced deficits only in Hdc+/+ mice as histamine deficiency prevented almost all the diet-related beneficial effects. Interpretation: Our results reveal a previously unexplored and novel role for brain histamine as a mediator of many favorable effects of the enriched diet. These data present long-reaching perspectives in the field of nutritional neuropsychopharmacology. View Full-Text
Keywords: Hdc null mice; n-3 LC-PUFA; long-term potentiation; oxylipins; social avoidance Hdc null mice; n-3 LC-PUFA; long-term potentiation; oxylipins; social avoidance
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MDPI and ACS Style

Costa, A.; Rani, B.; Bastiaanssen, T.F.S.; Bonfiglio, F.; Gunnigle, E.; Provensi, G.; Rossitto, M.; Boehme, M.; Strain, C.; Martínez, C.S.; Blandina, P.; Cryan, J.F.; Layé, S.; Corradetti, R.; Passani, M.B. Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner. Int. J. Mol. Sci. 2022, 23, 862. https://doi.org/10.3390/ijms23020862

AMA Style

Costa A, Rani B, Bastiaanssen TFS, Bonfiglio F, Gunnigle E, Provensi G, Rossitto M, Boehme M, Strain C, Martínez CS, Blandina P, Cryan JF, Layé S, Corradetti R, Passani MB. Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner. International Journal of Molecular Sciences. 2022; 23(2):862. https://doi.org/10.3390/ijms23020862

Chicago/Turabian Style

Costa, Alessia, Barbara Rani, Thomaz F.S. Bastiaanssen, Francesco Bonfiglio, Eoin Gunnigle, Gustavo Provensi, Moira Rossitto, Marcus Boehme, Conall Strain, Clara S. Martínez, Patrizio Blandina, John F. Cryan, Sophie Layé, Renato Corradetti, and Maria B. Passani. 2022. "Diet Prevents Social Stress-Induced Maladaptive Neurobehavioural and Gut Microbiota Changes in a Histamine-Dependent Manner" International Journal of Molecular Sciences 23, no. 2: 862. https://doi.org/10.3390/ijms23020862

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