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Nanomechanical Atomic Force Microscopy to Probe Cellular Microplastics Uptake and Distribution

Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, Kazan 420008, Republic of Tatarstan, Russian Federation
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Academic Editor: Dario Puppi
Int. J. Mol. Sci. 2022, 23(2), 806; https://doi.org/10.3390/ijms23020806
Received: 14 November 2021 / Revised: 30 December 2021 / Accepted: 8 January 2022 / Published: 12 January 2022
The concerns regarding microplastics and nanoplastics pollution stimulate studies on the uptake and biodistribution of these emerging pollutants in vitro. Atomic force microscopy in nanomechanical PeakForce Tapping mode was used here to visualise the uptake and distribution of polystyrene spherical microplastics in human skin fibroblast. Particles down to 500 nm were imaged in whole fixed cells, the nanomechanical characterization allowed for differentiation between internalized and surface attached plastics. This study opens new avenues in microplastics toxicity research. View Full-Text
Keywords: atomic force microscopy (AFM); human skin fibroblasts (HSF); microplastics; nanoplastics; dark-field hyperspectral microscopy; nanomechanical characteristics atomic force microscopy (AFM); human skin fibroblasts (HSF); microplastics; nanoplastics; dark-field hyperspectral microscopy; nanomechanical characteristics
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MDPI and ACS Style

Akhatova, F.; Ishmukhametov, I.; Fakhrullina, G.; Fakhrullin, R. Nanomechanical Atomic Force Microscopy to Probe Cellular Microplastics Uptake and Distribution. Int. J. Mol. Sci. 2022, 23, 806. https://doi.org/10.3390/ijms23020806

AMA Style

Akhatova F, Ishmukhametov I, Fakhrullina G, Fakhrullin R. Nanomechanical Atomic Force Microscopy to Probe Cellular Microplastics Uptake and Distribution. International Journal of Molecular Sciences. 2022; 23(2):806. https://doi.org/10.3390/ijms23020806

Chicago/Turabian Style

Akhatova, Farida, Ilnur Ishmukhametov, Gölnur Fakhrullina, and Rawil Fakhrullin. 2022. "Nanomechanical Atomic Force Microscopy to Probe Cellular Microplastics Uptake and Distribution" International Journal of Molecular Sciences 23, no. 2: 806. https://doi.org/10.3390/ijms23020806

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