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Review

DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain

1
Nociception Group, Department of Surgery and Cancer, Division of Anaesthetics, Pain Medicine and Intensive Care, Chelsea and Westminster Hospital Campus, Imperial College London, 369 Fulham Road, London SW10 9FJ, UK
2
Department of Brain Sciences, Division of Neuroscience, Imperial College London, E505, Burlington Danes, Du Cane Road, London W12 ONN, UK
3
Department of Brain Sciences, Dementia Research Institute, Imperial College London, 86 Wood Ln, London W12 0BZ, UK
4
Departament de Biologia Cellular, Biologia Funcional i Antropologia Física, Facultat de Ciències Biològiques, Universitat de València, C/Dr. Moliner 50, 46100 Burjassot, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the work.
Academic Editors: Anna Maria Aloisi and Valeria Bachiocco
Int. J. Mol. Sci. 2022, 23(2), 752; https://doi.org/10.3390/ijms23020752
Received: 8 December 2021 / Revised: 4 January 2022 / Accepted: 7 January 2022 / Published: 11 January 2022
(This article belongs to the Special Issue Molecular Mechanisms of Pain 2.0)
While about half of the population experience persistent pain associated with tissue damages during their lifetime, current symptom-based approaches often fail to reduce such pain to a satisfactory level. To provide better patient care, mechanism-based analgesic approaches must be developed, which necessitates a comprehensive understanding of the nociceptive mechanism leading to tissue injury-associated persistent pain. Epigenetic events leading the altered transcription in the nervous system are pivotal in the maintenance of pain in tissue injury. However, the mechanisms through which those events contribute to the persistence of pain are not fully understood. This review provides a summary and critical evaluation of two epigenetic mechanisms, DNA methylation and non-coding RNA expression, on transcriptional modulation in nociceptive pathways during the development of tissue injury-associated pain. We assess the pre-clinical data and their translational implication and evaluate the potential of controlling DNA methylation and non-coding RNA expression as novel analgesic approaches and/or biomarkers of persistent pain. View Full-Text
Keywords: epigenetic; neuropathic pain; nociception; gene transcription; dorsal root ganglion; spinal dorsal horn; miRNA; siRNA; lncRNA; CpG islands epigenetic; neuropathic pain; nociception; gene transcription; dorsal root ganglion; spinal dorsal horn; miRNA; siRNA; lncRNA; CpG islands
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MDPI and ACS Style

Irfan, J.; Febrianto, M.R.; Sharma, A.; Rose, T.; Mahmudzade, Y.; Di Giovanni, S.; Nagy, I.; Torres-Perez, J.V. DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain. Int. J. Mol. Sci. 2022, 23, 752. https://doi.org/10.3390/ijms23020752

AMA Style

Irfan J, Febrianto MR, Sharma A, Rose T, Mahmudzade Y, Di Giovanni S, Nagy I, Torres-Perez JV. DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain. International Journal of Molecular Sciences. 2022; 23(2):752. https://doi.org/10.3390/ijms23020752

Chicago/Turabian Style

Irfan, Jahanzaib, Muhammad R. Febrianto, Anju Sharma, Thomas Rose, Yasamin Mahmudzade, Simone Di Giovanni, Istvan Nagy, and Jose V. Torres-Perez. 2022. "DNA Methylation and Non-Coding RNAs during Tissue-Injury Associated Pain" International Journal of Molecular Sciences 23, no. 2: 752. https://doi.org/10.3390/ijms23020752

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