Investigation of the Associations of Novel Inflammatory Biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)—With the Severity of Coronary Artery Disease and Acute Coronary Syndrome Occurrence
Abstract
:1. Introduction
2. Results
2.1. Characteristics of Participants
2.2. Association between Measured and Derived Parameters and Severity of Cad
2.3. Association between Measured Parameters and Diagnosis
2.4. Association of Sii and Siri with Selected Parameters
3. Discussion
4. Materials and Methods
4.1. Study Population
4.2. Clinical and Laboratory Data
4.3. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | Values |
---|---|
N of participants [♂/♀] | 699 (444/256) |
Age [years] | 66.3 (29.5–93.3) |
BMI [kg/m2] | 27.8 (16.1–47.4) |
Cause of hospitalization [stable CAD/STEMI/NSTEMI/UA] | 366/147/108/78 |
Previous MI [yes/no] | 269/430 |
Total cholesterol (TC) [mg/dL] | 172.0 (70.3–338.3) |
High-density lipoprotein (HDL) [mg/dL] | 47.2 (10.4–113.2) |
Low-density lipoprotein (LDL) [mg/dL] | 95.7 (20.5–257.9) |
Triglycerides (TG) [mg/dL] | 113.9 (31.3–456.7) |
Hyperlipidemia [yes/no] (N = 644) | 377/267 |
Hypertension [yes/no] | 577/122 |
Smoking [active/former smoker/no] | 195/75/429 |
Type 2 diabetes mellitus (t2DM) [yes/pre-diabetes/no] | 236/30/433 |
Coronary Artery Surgery Study Class (CASSC) [0/1/2/3] | 177/193/174/155 |
Leukocytes [thousand cells/µL] (N = 694) | 8.0 (3.0–26.0) |
Platelet (PLT) [mcL] | 220 (150–445) |
Neutrophils [thousand cells/µL] | 4.8 (1.4–44.7) |
Monocytes [thousand cells/µL] | 0.7 (0.2–3.0) |
Lymphocytes [thousand cells/µL] | 1.9 (0.4–41.8) |
SII | 519 (26–4634) |
SIRI | 1.7 (0.06–27.9) |
Variable | CASSC 0 | CASSC 1 | CASSC 2 | CASSC 3 | p-Value |
---|---|---|---|---|---|
N of participants [♂/♀] | 85/92 | 124/69 | 127/47 | 107/48 | <0.001 |
Age [years] | 65.9 (36.7–91.5) | 65.2 (34.7–93.3) | 64.0 (33.6–89.2) | 68.9 (29.4–90.8) | 0.019 |
BMI [kg/m2] | 27.8 (17.3–47.4) | 27.1 (16.9–43.4) | 27.8 (17.4–44.6) | 28.3 (16.1–45.9) | 0.635 |
Cause of hospitalization [stable CAD/STEMI/NSTEMI/UA] | 147/8/12/10 | 71/63/36/23 | 81/39/30/24 | 67/37/30/21 | <0.001 |
Previous MI [yes/no] | 13/164 | 79/114 | 84/90 | 93/62 | <0.001 |
TC [mg/dL] | 179.4 (73.3–328.7) | 178.9 (70.3–331.7) | 165.5 (70.9–338.3) | 161.7 (84.4–310.8) | 0.007 |
HDL [mg/dL] | 53.8 (10.4–107.6) | 46.6 (20.5–97.4) | 46.7 (21.3–113.2) | 44.3 (14.6–89.2) | <0.001 |
LDL [mg/dL] | 95.8 (20.5–230.7) | 105.0 (23.5–251.7) | 94.0 (24.4–258.0) | 87.0 (22.3–228.3) | 0.048 |
TG [mg/dL] | 115.3 (31.3–340.0) | 110.6 (43.6–438.3) | 113.4 (38.0–456.7) | 115.4 (47.6–391.8) | 0.847 |
Hyperlipidemia [yes/no] | 89/71 | 115/61 | 92/70 | 81/65 | 0.197 |
Hypertension [yes/no] | 132/45 | 157/36 | 152/22 | 136/19 | 0.003 |
Smoking [active/former smoker/no] | 30/13/134 | 69/17/107 | 57/24/93 | 39/21/95 | <0.001 |
t2DM [yes/pre-diabetes/no] | 51/7/119 | 57/6/130 | 62/10/102 | 66/7/82 | 0.070 |
Leukocytes [thousand cells/µL] | 7.7 (3.9–21.2) | 8.1 (3.9–26.0) | 8.0 (3.6–19.6) | 8.2 (3.0–18.1) | 0.085 |
PLT [mcL] | 212 (150–445) | 224 (150–438) | 223 (151–439) | 218 (150–429) | 0.570 |
Neutrophils [thousand cells/µL] | 4.6 (1.7–44.7) | 4.8 (1.7–23.8) | 4.8 (1.4–16.8) | 5.0 (1.4–14.2) | 0.260 |
Monocytes [thousand cells/µL] | 0.7 (0.3–1.7) | 0.7 (0.3–2.4) | 0.7 (0.3–2.0) | 0.8 (0.2–3.0) | 0.046 |
Lymphocytes [thousand cells/µL] | 1.9 (0.4–4.6) | 2.1 (0.4–4.9) | 2.0 (0.7–41.8) | 1.9 (0.6–5.0) | 0.162 |
SII | 505 (103–4932) | 510 (142–4467) | 507 (26–2574) | 566 (136–4191) | 0.277 |
SIRI | 1.6 (0.3–16.7) | 1.7 (0.3–27.9) | 1.7 (0.1–19.4) | 1.9 (0.5–15.2) | 0.066 |
Variable | Stable CAD | STEMI | NSTEMI | UA | p-Value |
---|---|---|---|---|---|
Number of participants [♂/♀] | 225/141 | 110/37 | 67/41 | 41/37 | 0.005 |
Age [years] | 67.1 (29.4–93.3) | 63.0 (36.3–89.1) | 65.1 (36.1–92.1) | 69.6 (33.6–91.5) | <0.001 |
BMI [kg/m2] | 28.0 (16.1–47.4) | 26.9 (16.9–44.6) | 27.7 (17.8–42.4) | 28.6 (17.3–43.4) | 0.549 |
Previous MI [yes/no] | 109/257 | 71/76 | 63/45 | 26/52 | <0.001 |
TC [mg/dL] | 170.4 (84.8–328.7) | 180.6 (97.4–320.3) | 168.9 (70.3–338.3) | 159.2 (81.4–331.7) | 0.026 |
HDL [mg/dL] | 50.2 (10.4–113.2) | 45.0 (20.5–92.9) | 42.6 (22.8–78.9) | 46.5 (19.5–72.9) | <0.001 |
LDL [mg/dL] | 89.0 (20.5–258.0) | 108.2 (28.3–214.1) | 100.1 (23.5–244.3) | 86.8 (32.9–251.7) | <0.001 |
TG [mg/dL] | 115.8 (35.7–438.3) | 107.6 (47.6–367.8) | 111.2 (43.6–456.7) | 114.7 (31.3–251.7) | 0.971 |
Hyperlipidemia [yes/no] | 187/151 | 99/44 | 59/38 | 32/34 | 0.011 |
Hypertension [yes/no] | 289/77 | 119/28 | 93/15 | 76/2 | <0.001 |
Smoking [active/former smoker/no] | 70/56/240 | 67/8/72 | 45/3/60 | 13/8/57 | <0.001 |
t2DM [yes/pre-diabetes/no] | 127/16/223 | 44/3/100 | 33/8/67 | 32/3/43 | 0.236 |
Leukocytes [thousand cells/µL] | 7.8 (3.6–18.6) | 8.7 (3.0–26.0) | 7.9 (3.9–21.2) | 7.8 (4.7–19.6) | 0.0006 |
PLT [mcL] | 214 (150–445) | 230 (150–428) | 224 (151–410) | 219 (150–432) | 0.099 |
Neutrophils [thousand cells/µL] | 4.7 (1.4–44.7) | 5.3 (1.4–23.8) | 4.8 (1.7–19.3) | 4.8 (2.3–15.1) | 0.0008 |
Monocytes [thousand cells/µL] | 0.7 (0.2–1.8) | 0.8 (0.3–2.0) | 0.7 (0.3–3.0) | 0.7 (0.3–2.4) | 0.030 |
Lymphocytes [thousand cells/µL] | 1.9 (0.6–41.8) | 2.0 (0.6–5.3) | 1.9 (0.4–3.8) | 2.0 (0.4–4.6) | 0.756 |
SII | 494 (26–4634) | 579 (142–4467) | 576 (103–4491) | 563 (192–2482) | 0.0052 |
SIRI | 1.6 (0.1–26.2) | 2.0 (0.6–27.9) | 1.7 (0.3–15.8) | 1.7 (0.5–16.9) | 0.0053 |
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Dziedzic, E.A.; Gąsior, J.S.; Tuzimek, A.; Paleczny, J.; Junka, A.; Dąbrowski, M.; Jankowski, P. Investigation of the Associations of Novel Inflammatory Biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)—With the Severity of Coronary Artery Disease and Acute Coronary Syndrome Occurrence. Int. J. Mol. Sci. 2022, 23, 9553. https://doi.org/10.3390/ijms23179553
Dziedzic EA, Gąsior JS, Tuzimek A, Paleczny J, Junka A, Dąbrowski M, Jankowski P. Investigation of the Associations of Novel Inflammatory Biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)—With the Severity of Coronary Artery Disease and Acute Coronary Syndrome Occurrence. International Journal of Molecular Sciences. 2022; 23(17):9553. https://doi.org/10.3390/ijms23179553
Chicago/Turabian StyleDziedzic, Ewelina A., Jakub S. Gąsior, Agnieszka Tuzimek, Justyna Paleczny, Adam Junka, Marek Dąbrowski, and Piotr Jankowski. 2022. "Investigation of the Associations of Novel Inflammatory Biomarkers—Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)—With the Severity of Coronary Artery Disease and Acute Coronary Syndrome Occurrence" International Journal of Molecular Sciences 23, no. 17: 9553. https://doi.org/10.3390/ijms23179553