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Article

Neurogenesis Is Increased in Human Neural Stem Cells by Aβ40 Peptide

1
Unidad de Regeneración Neural, Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III (ISCIII), 28222 Majadahonda, Spain
2
Instituto de Investigación de Enfermedades Raras (IIER), Instituto de Salud Carlos III (ISCIII), 28222 Majadahonda, Spain
3
Unidad de Biología Computacional, Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III (ISCIII), 28222 Majadahonda, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Holger Wille and J. Carlos Villaescusa
Int. J. Mol. Sci. 2022, 23(10), 5820; https://doi.org/10.3390/ijms23105820
Received: 31 March 2022 / Revised: 3 May 2022 / Accepted: 20 May 2022 / Published: 22 May 2022
Amyloid-β 40 peptides [Aβ1-40 (Aβ40)] are present within amyloid plaques in the brains of patients with Alzheimer’s disease (AD). Even though Aβ peptides are considered neurotoxic, they can mediate many biological processes, both in adult brains and throughout brain development. However, the physiological function of these Aβ peptides remains poorly understood, and the existing data are sometimes controversial. Here, we analyze and compare the effects of monomeric Aβ40 on the biology of differentiating human neural stem cells (human NSCs). For that purpose, we used a model of human NSCs called hNS1. Our data demonstrated that Aβ40 at high concentrations provokes apoptotic cellular death and the damage of DNA in human NSCs while also increasing the proliferation and favors neurogenesis by raising the percentage of proliferating neuronal precursors. These effects can be mediated, at least in part, by β-catenin. These results provide evidence of how Aβ modulate/regulate human NSC proliferation and differentiation, suggesting Aβ40 may be a pro-neurogenic factor. Our data could contribute to a better understanding of the molecular mechanisms involved in AD pathology and to the development of human NSC-based therapies for AD treatment, since these results could then be used in diagnosing the disease at early stages and be applied to the development of new treatment options. View Full-Text
Keywords: Aβ40; human neural stem cells; Alzheimer’s; neurogenesis; cell proliferation Aβ40; human neural stem cells; Alzheimer’s; neurogenesis; cell proliferation
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MDPI and ACS Style

Bernabeu-Zornoza, A.; Coronel, R.; Palmer, C.; Martín, A.; López-Alonso, V.; Liste, I. Neurogenesis Is Increased in Human Neural Stem Cells by Aβ40 Peptide. Int. J. Mol. Sci. 2022, 23, 5820. https://doi.org/10.3390/ijms23105820

AMA Style

Bernabeu-Zornoza A, Coronel R, Palmer C, Martín A, López-Alonso V, Liste I. Neurogenesis Is Increased in Human Neural Stem Cells by Aβ40 Peptide. International Journal of Molecular Sciences. 2022; 23(10):5820. https://doi.org/10.3390/ijms23105820

Chicago/Turabian Style

Bernabeu-Zornoza, Adela, Raquel Coronel, Charlotte Palmer, Alberto Martín, Victoria López-Alonso, and Isabel Liste. 2022. "Neurogenesis Is Increased in Human Neural Stem Cells by Aβ40 Peptide" International Journal of Molecular Sciences 23, no. 10: 5820. https://doi.org/10.3390/ijms23105820

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