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Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory

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Dipartimento di Biologia e Biotecnologie “C. Darwin”, Sapienza Università di Roma, 00185 Rome, Italy
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Centro Nazionale per le Tecnologie Innovative in Sanità Pubblica (TISP), Istituto Superiore di Sanità (ISS), 00161 Rome, Italy
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Istituto Nazionale di Fisica Nucleare (INFN), Sezione Roma 1, 00185 Rome, Italy
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Dipartimento di Medicina Clinica, Sanità Pubblica, Scienze Della Vita e Dell’ambiente, Università Dell’aquila, 67100 L’Aquila, Italy
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Fondazione Cenci Bolognetti, Istituto Pasteur, 00185 Rome, Italy
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Laboratori Nazionali del Gran Sasso (LNGS), INFN, Assergi, 67100 L’Aquila, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Thomas C. Irving
Int. J. Mol. Sci. 2022, 23(10), 5472; https://doi.org/10.3390/ijms23105472 (registering DOI)
Received: 12 April 2022 / Revised: 10 May 2022 / Accepted: 11 May 2022 / Published: 13 May 2022
A large amount of evidence from radiobiology studies carried out in Deep Underground Laboratories support the view that environmental radiation may trigger biological mechanisms that enable both simple and complex organisms to cope with genotoxic stress. In line with this, here we show that the reduced radiation background of the LNGS underground laboratory renders Drosophila neuroblasts more sensitive to ionizing radiation-induced (but not to spontaneous) DNA breaks compared to fruit flies kept at the external reference laboratory. Interestingly, we demonstrate that the ionizing radiation sensitivity of flies kept at the LNGS underground laboratory is rescued by increasing the underground gamma dose rate to levels comparable to the low-LET reference one. This finding provides the first direct evidence that the modulation of the DNA damage response in a complex multicellular organism is indeed dependent on the environmental dose rate. View Full-Text
Keywords: environmental radiation; deep underground laboratory; Drosophila melanogaster; chromosome aberrations; dose rate effect environmental radiation; deep underground laboratory; Drosophila melanogaster; chromosome aberrations; dose rate effect
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MDPI and ACS Style

Porrazzo, A.; Esposito, G.; Grifoni, D.; Cenci, G.; Morciano, P.; Tabocchini, M.A. Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory. Int. J. Mol. Sci. 2022, 23, 5472. https://doi.org/10.3390/ijms23105472

AMA Style

Porrazzo A, Esposito G, Grifoni D, Cenci G, Morciano P, Tabocchini MA. Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory. International Journal of Molecular Sciences. 2022; 23(10):5472. https://doi.org/10.3390/ijms23105472

Chicago/Turabian Style

Porrazzo, Antonella, Giuseppe Esposito, Daniela Grifoni, Giovanni Cenci, Patrizia Morciano, and Maria A. Tabocchini. 2022. "Reduced Environmental Dose Rates Are Responsible for the Increased Susceptibility to Radiation-Induced DNA Damage in Larval Neuroblasts of Drosophila Grown inside the LNGS Underground Laboratory" International Journal of Molecular Sciences 23, no. 10: 5472. https://doi.org/10.3390/ijms23105472

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