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Article

Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease

1
Department of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
2
Croatian Institute for Brain Research, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Those authors contributed equally to this work.
Academic Editor: Marcus O. W. Grimm
Int. J. Mol. Sci. 2022, 23(1), 548; https://doi.org/10.3390/ijms23010548
Received: 24 November 2021 / Revised: 27 December 2021 / Accepted: 29 December 2021 / Published: 4 January 2022
(This article belongs to the Special Issue The Links between Nutrition, Energy Metabolism, Aging and Cognition)
The incretin system is an emerging new field that might provide valuable contributions to the research of both the pathophysiology and therapeutic strategies in the treatment of diabetes, obesity, and neurodegenerative disorders. This study aimed to explore the roles of central glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) on cell metabolism and energy in the brain, as well as on the levels of these incretins, insulin, and glucose via inhibition of the central incretin receptors following intracerebroventricular administration of the respective antagonists in healthy rats and a streptozotocin-induced rat model of sporadic Alzheimer’s disease (sAD). Chemical ablation of the central GIP receptor (GIPR) or GLP-1 receptor (GLP-1R) in healthy and diseased animals indicated a region-dependent role of incretins in brain cell energy and metabolism and central incretin-dependent modulation of peripheral hormone secretion, markedly after GIPR inhibition, as well as a dysregulation of the GLP-1 system in experimental sAD. View Full-Text
Keywords: glucagon-like peptide-1; gastric inhibitory polypeptide; hippocampus; hypothalamus; Alzheimer’s disease glucagon-like peptide-1; gastric inhibitory polypeptide; hippocampus; hypothalamus; Alzheimer’s disease
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MDPI and ACS Style

Osmanovic Barilar, J.; Knezovic, A.; Homolak, J.; Babic Perhoc, A.; Salkovic-Petrisic, M. Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease. Int. J. Mol. Sci. 2022, 23, 548. https://doi.org/10.3390/ijms23010548

AMA Style

Osmanovic Barilar J, Knezovic A, Homolak J, Babic Perhoc A, Salkovic-Petrisic M. Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease. International Journal of Molecular Sciences. 2022; 23(1):548. https://doi.org/10.3390/ijms23010548

Chicago/Turabian Style

Osmanovic Barilar, Jelena, Ana Knezovic, Jan Homolak, Ana Babic Perhoc, and Melita Salkovic-Petrisic. 2022. "Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease" International Journal of Molecular Sciences 23, no. 1: 548. https://doi.org/10.3390/ijms23010548

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