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Review

MicroRNAs in Acute ST Elevation Myocardial Infarction—A New Tool for Diagnosis and Prognosis: Therapeutic Implications

1
Department of Cardiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania
2
Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Anindita Das
Int. J. Mol. Sci. 2021, 22(9), 4799; https://doi.org/10.3390/ijms22094799
Received: 15 March 2021 / Revised: 23 April 2021 / Accepted: 26 April 2021 / Published: 30 April 2021
(This article belongs to the Special Issue Molecular Research in Cardiovascular Disease)
Despite diagnostic and therapeutic advances, coronary artery disease and especially its extreme manifestation, ST elevation myocardial infarction (STEMI), remain the leading causes of morbidity and mortality worldwide. Early and prompt diagnosis is of great importance regarding the prognosis of STEMI patients. In recent years, microRNAs (miRNAs) have emerged as promising tools involved in many pathophysiological processes in various fields, including cardiovascular diseases. In acute coronary syndromes (ACS), circulating levels of miRNAs are significantly elevated, as an indicator of cardiac damage, making them a promising marker for early diagnosis of myocardial infarction. They also have prognostic value and great potential as therapeutic targets considering their key function in gene regulation. This review aims to summarize current information about miRNAs and their role as diagnostic, prognostic and therapeutic targets in STEMI patients. View Full-Text
Keywords: miRNA; STEMI; biomarkers miRNA; STEMI; biomarkers
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MDPI and ACS Style

Scărlătescu, A.I.; Micheu, M.M.; Popa-Fotea, N.-M.; Dorobanțu, M. MicroRNAs in Acute ST Elevation Myocardial Infarction—A New Tool for Diagnosis and Prognosis: Therapeutic Implications. Int. J. Mol. Sci. 2021, 22, 4799. https://doi.org/10.3390/ijms22094799

AMA Style

Scărlătescu AI, Micheu MM, Popa-Fotea N-M, Dorobanțu M. MicroRNAs in Acute ST Elevation Myocardial Infarction—A New Tool for Diagnosis and Prognosis: Therapeutic Implications. International Journal of Molecular Sciences. 2021; 22(9):4799. https://doi.org/10.3390/ijms22094799

Chicago/Turabian Style

Scărlătescu, Alina Ioana, Miruna Mihaela Micheu, Nicoleta-Monica Popa-Fotea, and Maria Dorobanțu. 2021. "MicroRNAs in Acute ST Elevation Myocardial Infarction—A New Tool for Diagnosis and Prognosis: Therapeutic Implications" International Journal of Molecular Sciences 22, no. 9: 4799. https://doi.org/10.3390/ijms22094799

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