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Review

Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review

1
Pittsburgh Center for Pain Research, and the Pittsburgh Project to End Opioid Misuse, Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
2
Department of Biology, Texas Woman’s University, Denton, TX 76204-5799, USA
3
Department of Kinesiology and Nutrition Sciences, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV 89154, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Sara Marinelli
Int. J. Mol. Sci. 2021, 22(9), 4666; https://doi.org/10.3390/ijms22094666
Received: 21 March 2021 / Revised: 22 April 2021 / Accepted: 26 April 2021 / Published: 28 April 2021
(This article belongs to the Special Issue The Multiple Mechanisms Underlying Neuropathic Pain)
Lesion or disease of the somatosensory system leads to the development of neuropathic pain. Peripheral neuropathic pain encompasses damage or injury of the peripheral nervous system. On the other hand, 10–15% of individuals suffer from acute postoperative pain followed by persistent pain after undergoing surgeries. Antidepressants, anticonvulsants, baclofen, and clonidine are used to treat peripheral neuropathy, whereas opioids are used to treat postoperative pain. The negative effects associated with these drugs emphasize the search for alternative therapeutics with better efficacy and fewer side effects. Curcumin, a polyphenol isolated from the roots of Curcuma longa, possesses antibacterial, antioxidant, and anti-inflammatory properties. Furthermore, the low bioavailability and fast metabolism of curcumin have led to the advent of various curcumin formulations. The present review provides a comprehensive analysis on the effects of curcumin and its formulations in preclinical and clinical studies of neuropathic and postoperative pain. Based on the positive outcomes from both preclinical and clinical studies, curcumin holds the promise of mitigating or preventing neuropathic and postoperative pain conditions. However, more clinical studies with improved curcumin formulations are required to involve its use as adjuvant to neuropathic and postoperative drugs. View Full-Text
Keywords: curcumin; curcumin formulations; diabetes; peripheral neuropathy; postoperative pain; preemptive analgesia curcumin; curcumin formulations; diabetes; peripheral neuropathy; postoperative pain; preemptive analgesia
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MDPI and ACS Style

Basu, P.; Maier, C.; Basu, A. Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review. Int. J. Mol. Sci. 2021, 22, 4666. https://doi.org/10.3390/ijms22094666

AMA Style

Basu P, Maier C, Basu A. Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review. International Journal of Molecular Sciences. 2021; 22(9):4666. https://doi.org/10.3390/ijms22094666

Chicago/Turabian Style

Basu, Paramita, Camelia Maier, and Arpita Basu. 2021. "Effects of Curcumin and Its Different Formulations in Preclinical and Clinical Studies of Peripheral Neuropathic and Postoperative Pain: A Comprehensive Review" International Journal of Molecular Sciences 22, no. 9: 4666. https://doi.org/10.3390/ijms22094666

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