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Prebiotic Pathway from Ribose to RNA Formation

Department of Molecular Biotechnology and Microbiology, University of Debrecen, 1 Egyetem Square, 4010 Debrecen, Hungary
Academic Editor: Giuseppe Biamonti
Int. J. Mol. Sci. 2021, 22(8), 3857; https://doi.org/10.3390/ijms22083857
Received: 29 January 2021 / Revised: 31 March 2021 / Accepted: 6 April 2021 / Published: 8 April 2021
(This article belongs to the Special Issue Ribose Selected as Precursor to Life)
At the focus of abiotic chemical reactions is the synthesis of ribose. No satisfactory explanation was provided as to the missing link between the prebiotic synthesis of ribose and prebiotic RNA (preRNA). Hydrogen cyanide (HCN) is assumed to have been the principal precursor in the prebiotic formation of aldopentoses in the formose reaction and in the synthesis of ribose. Ribose as the best fitting aldopentose became the exclusive sugar component of RNA. The elevated yield of ribose synthesis at higher temperatures and its protection from decomposition could have driven the polymerization of the ribose-phosphate backbone and the coupling of nucleobases to the backbone. RNA could have come into being without the involvement of nucleotide precursors. The first nucleoside monophosphate is likely to have appeared upon the hydrolysis of preRNA contributed by the presence of reactive 2′-OH moieties in the preRNA chain. As a result of phosphorylation, nucleoside monophosphates became nucleoside triphosphates, substrates for the selective synthesis of genRNA. View Full-Text
Keywords: ribose formation; fitting of aldopentoses; preRNA synthesis; hydrolysis of preRNA; phosphorylation of NMPs; genRNA synthesis ribose formation; fitting of aldopentoses; preRNA synthesis; hydrolysis of preRNA; phosphorylation of NMPs; genRNA synthesis
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MDPI and ACS Style

Banfalvi, G. Prebiotic Pathway from Ribose to RNA Formation. Int. J. Mol. Sci. 2021, 22, 3857. https://doi.org/10.3390/ijms22083857

AMA Style

Banfalvi G. Prebiotic Pathway from Ribose to RNA Formation. International Journal of Molecular Sciences. 2021; 22(8):3857. https://doi.org/10.3390/ijms22083857

Chicago/Turabian Style

Banfalvi, Gaspar. 2021. "Prebiotic Pathway from Ribose to RNA Formation" International Journal of Molecular Sciences 22, no. 8: 3857. https://doi.org/10.3390/ijms22083857

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