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Review

Acceptive Immunity: The Role of Fucosylated Glycans in Human Host–Microbiome Interactions

by
Svetlana Kononova
1,2,*,
Ekaterina Litvinova
3,4,
Timur Vakhitov
1,
Maria Skalinskaya
1,5 and
Stanislav Sitkin
1,5,6
1
Department of Microbiology, State Research Institute of Highly Pure Biopreparations, 197110 St. Petersburg, Russia
2
Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Russia
3
Scientific-Research Institute of Neurosciences and Medicine, 630117 Novosibirsk, Russia
4
Siberian Federal Scientific Center of Agro-BioTechnologies, Russian Academy of Sciences, Krasnoobsk, 633501 Novosibirsk, Russia
5
Department of Internal Diseases, Gastroenterology and Dietetics, North-Western State Medical University Named after I.I. Mechnikov, 191015 St. Petersburg, Russia
6
Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, 197341 St. Petersburg, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(8), 3854; https://doi.org/10.3390/ijms22083854
Submission received: 5 March 2021 / Revised: 4 April 2021 / Accepted: 5 April 2021 / Published: 8 April 2021
(This article belongs to the Special Issue Gut Microbiota and Immunity)
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Abstract

The growth in the number of chronic non-communicable diseases in the second half of the past century and in the first two decades of the new century is largely due to the disruption of the relationship between the human body and its symbiotic microbiota, and not pathogens. The interaction of the human immune system with symbionts is not accompanied by inflammation, but is a physiological norm. This is achieved via microbiota control by the immune system through a complex balance of pro-inflammatory and suppressive responses, and only a disturbance of this balance can trigger pathophysiological mechanisms. This review discusses the establishment of homeostatic relationships during immune system development and intestinal bacterial colonization through the interaction of milk glycans, mucins, and secretory immunoglobulins. In particular, the role of fucose and fucosylated glycans in the mechanism of interactions between host epithelial and immune cells is discussed.
Keywords: intestinal microbiota; acceptive immunity; immune tolerance; fucose; fucosylated glycans; host–microbiome interactions intestinal microbiota; acceptive immunity; immune tolerance; fucose; fucosylated glycans; host–microbiome interactions

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MDPI and ACS Style

Kononova, S.; Litvinova, E.; Vakhitov, T.; Skalinskaya, M.; Sitkin, S. Acceptive Immunity: The Role of Fucosylated Glycans in Human Host–Microbiome Interactions. Int. J. Mol. Sci. 2021, 22, 3854. https://doi.org/10.3390/ijms22083854

AMA Style

Kononova S, Litvinova E, Vakhitov T, Skalinskaya M, Sitkin S. Acceptive Immunity: The Role of Fucosylated Glycans in Human Host–Microbiome Interactions. International Journal of Molecular Sciences. 2021; 22(8):3854. https://doi.org/10.3390/ijms22083854

Chicago/Turabian Style

Kononova, Svetlana, Ekaterina Litvinova, Timur Vakhitov, Maria Skalinskaya, and Stanislav Sitkin. 2021. "Acceptive Immunity: The Role of Fucosylated Glycans in Human Host–Microbiome Interactions" International Journal of Molecular Sciences 22, no. 8: 3854. https://doi.org/10.3390/ijms22083854

APA Style

Kononova, S., Litvinova, E., Vakhitov, T., Skalinskaya, M., & Sitkin, S. (2021). Acceptive Immunity: The Role of Fucosylated Glycans in Human Host–Microbiome Interactions. International Journal of Molecular Sciences, 22(8), 3854. https://doi.org/10.3390/ijms22083854

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