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Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome

1
Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
2
Department of Thermal Technology and Food Process Engineering, University of Life Sciences in Lublin, Głęboka 31, 20-612 Lublin, Poland
3
Institute of Agrophysics, Polish Academy of Sciences, Doświadczalna 4, 20-290 Lublin, Poland
*
Authors to whom correspondence should be addressed.
Academic Editor: Francesca Truzzi
Int. J. Mol. Sci. 2021, 22(7), 3715; https://doi.org/10.3390/ijms22073715
Received: 28 February 2021 / Revised: 25 March 2021 / Accepted: 30 March 2021 / Published: 2 April 2021
(This article belongs to the Special Issue Medical Plants and Polyphenols)
The human intestine contains an intricate community of microorganisms, referred to as the gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple factors could interfere with this delicate balance, including genetics, age, medicines and environmental factors, particularly diet. Growing evidence supports the involvement of GM dysbiosis in gastrointestinal (GI) and extraintestinal metabolic diseases. The beneficial effects of dietary polyphenols in preventing metabolic diseases have been subjected to intense investigation over the last twenty years. As our understanding of the role of the gut microbiota advances and our knowledge of the antioxidant and anti-inflammatory functions of polyphenols accumulates, there emerges a need to examine the prebiotic role of dietary polyphenols. This review firstly overviews the importance of the GM in health and disease and then reviews the role of dietary polyphenols on the modulation of the gut microbiota, their metabolites and how they impact on host health benefits. Inter-dependence between the gut microbiota and polyphenol metabolites and the vital balance between the two in maintaining the host gut homeostasis are also discussed. View Full-Text
Keywords: gut microbiota; dysbiosis; polyphenols; metabolic syndrome; metabolic diseases; type 2 diabetes; obesity; cardiovascular diseases gut microbiota; dysbiosis; polyphenols; metabolic syndrome; metabolic diseases; type 2 diabetes; obesity; cardiovascular diseases
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MDPI and ACS Style

Kasprzak-Drozd, K.; Oniszczuk, T.; Stasiak, M.; Oniszczuk, A. Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome. Int. J. Mol. Sci. 2021, 22, 3715. https://doi.org/10.3390/ijms22073715

AMA Style

Kasprzak-Drozd K, Oniszczuk T, Stasiak M, Oniszczuk A. Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome. International Journal of Molecular Sciences. 2021; 22(7):3715. https://doi.org/10.3390/ijms22073715

Chicago/Turabian Style

Kasprzak-Drozd, Kamila; Oniszczuk, Tomasz; Stasiak, Mateusz; Oniszczuk, Anna. 2021. "Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome" Int. J. Mol. Sci. 22, no. 7: 3715. https://doi.org/10.3390/ijms22073715

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