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Review

Molecular Mechanism of Cannabinoids in Cancer Progression

1
Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, Italy
2
Institute of Endocrinology and Experimental Oncology, IEOS CNR, Via Pansini 5, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Contributed equally to this work.
Academic Editor: Eberhard Schlicker
Int. J. Mol. Sci. 2021, 22(7), 3680; https://doi.org/10.3390/ijms22073680
Received: 9 March 2021 / Revised: 28 March 2021 / Accepted: 28 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Molecular Relationship between Endocannabinoid System and Disease)
Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer proliferation, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis. View Full-Text
Keywords: cannabinoids; cell death; migration; angiogenesis; cancer cannabinoids; cell death; migration; angiogenesis; cancer
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MDPI and ACS Style

Pagano, C.; Navarra, G.; Coppola, L.; Bifulco, M.; Laezza, C. Molecular Mechanism of Cannabinoids in Cancer Progression. Int. J. Mol. Sci. 2021, 22, 3680. https://doi.org/10.3390/ijms22073680

AMA Style

Pagano C, Navarra G, Coppola L, Bifulco M, Laezza C. Molecular Mechanism of Cannabinoids in Cancer Progression. International Journal of Molecular Sciences. 2021; 22(7):3680. https://doi.org/10.3390/ijms22073680

Chicago/Turabian Style

Pagano, Cristina, Giovanna Navarra, Laura Coppola, Maurizio Bifulco, and Chiara Laezza. 2021. "Molecular Mechanism of Cannabinoids in Cancer Progression" International Journal of Molecular Sciences 22, no. 7: 3680. https://doi.org/10.3390/ijms22073680

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