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Article

The Impact of Spaceflight and Microgravity on the Human Islet-1+ Cardiovascular Progenitor Cell Transcriptome

1
Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
2
Department of Cardiovascular and Thoracic Surgery, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Daniela Grimm
Int. J. Mol. Sci. 2021, 22(7), 3577; https://doi.org/10.3390/ijms22073577
Received: 1 March 2021 / Revised: 27 March 2021 / Accepted: 27 March 2021 / Published: 30 March 2021
(This article belongs to the Special Issue Microgravity and Space Medicine)
Understanding the transcriptomic impact of microgravity and the spaceflight environment is relevant for future missions in space and microgravity-based applications designed to benefit life on Earth. Here, we investigated the transcriptome of adult and neonatal cardiovascular progenitors following culture aboard the International Space Station for 30 days and compared it to the transcriptome of clonally identical cells cultured on Earth. Cardiovascular progenitors acquire a gene expression profile representative of an early-stage, dedifferentiated, stem-like state, regardless of age. Signaling pathways that support cell proliferation and survival were induced by spaceflight along with transcripts related to cell cycle re-entry, cardiovascular development, and oxidative stress. These findings contribute new insight into the multifaceted influence of reduced gravitational environments. View Full-Text
Keywords: transcriptomics; spaceflight; microgravity; stemness; proliferation; miRNA; cardiovascular transcriptomics; spaceflight; microgravity; stemness; proliferation; miRNA; cardiovascular
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MDPI and ACS Style

Camberos, V.; Baio, J.; Mandujano, A.; Martinez, A.F.; Bailey, L.; Hasaniya, N.; Kearns-Jonker, M. The Impact of Spaceflight and Microgravity on the Human Islet-1+ Cardiovascular Progenitor Cell Transcriptome. Int. J. Mol. Sci. 2021, 22, 3577. https://doi.org/10.3390/ijms22073577

AMA Style

Camberos V, Baio J, Mandujano A, Martinez AF, Bailey L, Hasaniya N, Kearns-Jonker M. The Impact of Spaceflight and Microgravity on the Human Islet-1+ Cardiovascular Progenitor Cell Transcriptome. International Journal of Molecular Sciences. 2021; 22(7):3577. https://doi.org/10.3390/ijms22073577

Chicago/Turabian Style

Camberos, Victor, Jonathan Baio, Ana Mandujano, Aida F. Martinez, Leonard Bailey, Nahidh Hasaniya, and Mary Kearns-Jonker. 2021. "The Impact of Spaceflight and Microgravity on the Human Islet-1+ Cardiovascular Progenitor Cell Transcriptome" International Journal of Molecular Sciences 22, no. 7: 3577. https://doi.org/10.3390/ijms22073577

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