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RNA Helicases as Shadow Modulators of Cell Cycle Progression

Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30b1, 121205 Moscow, Russia
Department of Chemistry, Lomonosov Moscow State University, 119992 Moscow, Russia
Author to whom correspondence should be addressed.
Academic Editors: Joo Hyoung Lee and Tae-Don Kim
Int. J. Mol. Sci. 2021, 22(6), 2984;
Received: 11 February 2021 / Revised: 6 March 2021 / Accepted: 10 March 2021 / Published: 15 March 2021
The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-dependent kinases. However, many proteins that control DNA replication, RNA transcription and the synthesis and degradation of proteins can manage the activity or levels of master cell cycle regulators. Among them, RNA helicases are key participants in RNA metabolism involved in the global or specific tuning of cell cycle regulators at the level of transcription and translation. Several RNA helicases have been recently evaluated as promising therapeutic targets, including eIF4A, DDX3 and DDX5. However, targeting RNA helicases can result in side effects due to the influence on the cell cycle. In this review, we discuss direct and indirect participation of RNA helicases in the regulation of the cell cycle in order to draw attention to downstream events that may occur after suppression or inhibition of RNA helicases. View Full-Text
Keywords: RNA helicases; cell cycle; regulation RNA helicases; cell cycle; regulation
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MDPI and ACS Style

Sergeeva, O.; Zatsepin, T. RNA Helicases as Shadow Modulators of Cell Cycle Progression. Int. J. Mol. Sci. 2021, 22, 2984.

AMA Style

Sergeeva O, Zatsepin T. RNA Helicases as Shadow Modulators of Cell Cycle Progression. International Journal of Molecular Sciences. 2021; 22(6):2984.

Chicago/Turabian Style

Sergeeva, Olga, and Timofei Zatsepin. 2021. "RNA Helicases as Shadow Modulators of Cell Cycle Progression" International Journal of Molecular Sciences 22, no. 6: 2984.

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