Advanced Spheroid, Tumouroid and 3D Bioprinted In-Vitro Models of Adult and Paediatric Glioblastoma
Round 1
Reviewer 1 Report
Dear Authors,
The article presents an interesting review of the literature on the state of interdisciplinary knowledge on the actual use of 3D bio-printing in medicine. Chapter 3.1 on Three-dimensional in-vitro models of glioblastoma is of particular interest.
It seems, however, that there are several issues that can be improved at work:
- In Chapter 6, I propose to describe in more detail 3D printing technologies from biomaterials and existing machines 3D printers.
- In Chapter 1, I also recommend mentioning other potential applications of 3D printing in medicine, e.g. using FDM and electrospinning technology (Electrospinning on 3D Printed Polymers for Mechanically Stabilized Filter Composites, DOI: 10.3390 / polym11122034,
- In chapter 6 I recommend to add proto of already printed models in biopriting and e.g. from some CT, X-Ray ect.
- In Chapter 7 I also propose to mention the future trends in bio-printing development and the challenges.
With these changes, it appears the article may be republished in such form.
Regards,
Reviewer
Author Response
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Author Response File: Author Response.docx
Reviewer 2 Report
The authors reviewed the currently available in-vitro models of high-grade gliomas (HGG), with special attention to the pediatric HGG, concluding that, compared to the models of adult HGG, more researches are necessary for the pediatric ones.
I really enjoyed reading this manuscript, and both the references and the figures clarify and support the whole work.
I have only a question: which is, according to the authors' findings, the most promising way to better develop and improve pediatric models of HGG for future researches (if there is one)?
Author Response
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Author Response File: Author Response.docx