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Volume 22
Issue 6
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Review
Peer-Review Record

Advanced Spheroid, Tumouroid and 3D Bioprinted In-Vitro Models of Adult and Paediatric Glioblastoma

Int. J. Mol. Sci. 2021, 22(6), 2962; https://doi.org/10.3390/ijms22062962
by Louise Orcheston-Findlay 1, Samuel Bax 1, Robert Utama 2, Martin Engel 2, Dinisha Govender 3 and Geraldine O’Neill 1,4,5,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(6), 2962; https://doi.org/10.3390/ijms22062962
Submission received: 26 February 2021 / Revised: 5 March 2021 / Accepted: 5 March 2021 / Published: 15 March 2021
(This article belongs to the Special Issue Novel Therapeutic Treatments to Target Glioblastoma Intratumoral Heterogeneity and Plasticity)

Round 1

Reviewer 1 Report

Dear Authors,

The article presents an interesting review of the literature on the state of interdisciplinary knowledge on the actual use of 3D bio-printing in medicine. Chapter 3.1 on Three-dimensional in-vitro models of glioblastoma is of particular interest.

It seems, however, that there are several issues that can be improved at work:

  • In Chapter 6, I propose to describe in more detail 3D printing technologies from biomaterials and existing machines 3D printers.
  • In Chapter 1, I also recommend mentioning other potential applications of 3D printing in medicine, e.g. using FDM and electrospinning technology (Electrospinning on 3D Printed Polymers for Mechanically Stabilized Filter Composites, DOI: 10.3390 / polym11122034,
  • In chapter 6 I recommend to add proto of already printed models in biopriting and e.g. from some CT, X-Ray ect.
  • In Chapter 7 I also propose to mention the future trends in bio-printing development and the challenges.

With these changes, it appears the article may be republished in such form.

Regards,

Reviewer

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

The authors reviewed the currently available in-vitro models of high-grade gliomas (HGG), with special attention to the pediatric HGG, concluding that, compared to the models of adult HGG, more researches are necessary for the pediatric ones.

I really enjoyed reading this manuscript, and both the references and the figures clarify and support the whole work.

I have only a question: which is, according to the authors' findings, the most promising way to better develop and improve pediatric models of HGG for future researches (if there is one)?

Author Response

Please see the attachment

Author Response File: Author Response.docx

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