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Article

Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner

1
School of Medical Science, Griffith University, Gold Coast, QLD 4222, Australia
2
Institute of Health and Biomedical Innovation, Queensland University of Technology, South Brisbane, QLD 4001, Australia
3
School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia
4
Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia
5
School of Allied Health Sciences, Griffith University, Gold Coast, QLD 4222, Australia
6
Institute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia
7
Australian Institute for Musculoskeletal Science (AIMSS), Victoria University, St. Albans, VIC 3021, Australia
8
School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia
9
Environmental Futures Research Institute, Griffith University, Nathan, QLD 4111, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Paschalis Alexandridis
Int. J. Mol. Sci. 2021, 22(6), 2946; https://doi.org/10.3390/ijms22062946
Received: 5 February 2021 / Revised: 8 March 2021 / Accepted: 12 March 2021 / Published: 14 March 2021
Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. We aimed to investigate the effect of maternal and postnatal high LA (HLA) diet on plasma FA composition, plasma and hepatic lipids and genes involved in lipid metabolism in the liver of adult offspring. Female rats were fed with low LA (LLA; 1.44% LA) or HLA (6.21% LA) diets for 10 weeks before pregnancy, and during gestation/lactation. Offspring were weaned at postnatal day 25 (PN25), fed either LLA or HLA diets and sacrificed at PN180. Postnatal HLA diet decreased circulating total n-3 PUFA and alpha-linolenic acid (ALA), while increased total n-6 PUFA, LA and arachidonic acid (AA) in both male and female offspring. Maternal HLA diet increased circulating leptin in female offspring, but not in males. Maternal HLA diet decreased circulating adiponectin in males. Postnatal HLA diet significantly decreased aspartate transaminase (AST) in females and downregulated total cholesterol, HDL-cholesterol and triglycerides in the plasma of males. Maternal HLA diet downregulated the hepatic mRNA expression of Hmgcr in both male and female offspring and decreased the hepatic mRNA expression of Cpt1a and Acox1 in females. Both maternal and postnatal HLA diet decreased hepatic mRNA expression of Cyp27a1 in females. Postnatal diet significantly altered circulating fatty acid concentrations, with sex-specific differences in genes that control lipid metabolism in the adult offspring following exposure to high LA diet in utero. View Full-Text
Keywords: fetal programming; linoleic acid; lipid metabolism; liver; maternal; postnatal fetal programming; linoleic acid; lipid metabolism; liver; maternal; postnatal
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MDPI and ACS Style

Shrestha, N.; Vidimce, J.; Holland, O.J.; Cuffe, J.S.M.; Beck, B.R.; Perkins, A.V.; McAinch, A.J.; Hryciw, D.H. Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner. Int. J. Mol. Sci. 2021, 22, 2946. https://doi.org/10.3390/ijms22062946

AMA Style

Shrestha N, Vidimce J, Holland OJ, Cuffe JSM, Beck BR, Perkins AV, McAinch AJ, Hryciw DH. Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner. International Journal of Molecular Sciences. 2021; 22(6):2946. https://doi.org/10.3390/ijms22062946

Chicago/Turabian Style

Shrestha, Nirajan, Josif Vidimce, Olivia J. Holland, James S. M. Cuffe, Belinda R. Beck, Anthony V. Perkins, Andrew J. McAinch, and Deanne H. Hryciw. 2021. "Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner" International Journal of Molecular Sciences 22, no. 6: 2946. https://doi.org/10.3390/ijms22062946

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