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Article

Remapping of Adult-Born Neuron Activity during Fear Memory Consolidation in Mice

1
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan
2
Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan
3
Doctoral Program in Neuroscience, Degree Programs in Comprehensive Human Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Estela Castilla Ortega
Int. J. Mol. Sci. 2021, 22(6), 2874; https://doi.org/10.3390/ijms22062874
Received: 2 February 2021 / Revised: 3 March 2021 / Accepted: 10 March 2021 / Published: 12 March 2021
(This article belongs to the Special Issue Molecular and Functional Aspects of Adult Neurogenesis)
The mammalian hippocampal dentate gyrus is a unique memory circuit in which a subset of neurons is continuously generated throughout the lifespan. Previous studies have shown that the dentate gyrus neuronal population can hold fear memory traces (i.e., engrams) and that adult-born neurons (ABNs) support this process. However, it is unclear whether ABNs themselves hold fear memory traces. Therefore, we analyzed ABN activity at a population level across a fear conditioning paradigm. We found that fear learning did not recruit a distinct ABN population. In sharp contrast, a completely different ABN population was recruited during fear memory retrieval. We further provide evidence that ABN population activity remaps over time during the consolidation period. These results suggest that ABNs support the establishment of a fear memory trace in a different manner to directly holding the memory. Moreover, this activity remapping process in ABNs may support the segregation of memories formed at different times. These results provide new insight into the role of adult neurogenesis in the mammalian memory system. View Full-Text
Keywords: hippocampus; adult neurogenesis; memory; contextual fear conditioning; calcium imaging; sleep hippocampus; adult neurogenesis; memory; contextual fear conditioning; calcium imaging; sleep
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MDPI and ACS Style

Vergara, P.; Kumar, D.; Srinivasan, S.; Koyanagi, I.; Naoi, T.; Singh, S.; Sakaguchi, M. Remapping of Adult-Born Neuron Activity during Fear Memory Consolidation in Mice. Int. J. Mol. Sci. 2021, 22, 2874. https://doi.org/10.3390/ijms22062874

AMA Style

Vergara P, Kumar D, Srinivasan S, Koyanagi I, Naoi T, Singh S, Sakaguchi M. Remapping of Adult-Born Neuron Activity during Fear Memory Consolidation in Mice. International Journal of Molecular Sciences. 2021; 22(6):2874. https://doi.org/10.3390/ijms22062874

Chicago/Turabian Style

Vergara, Pablo, Deependra Kumar, Sakthivel Srinivasan, Iyo Koyanagi, Toshie Naoi, Sima Singh, and Masanori Sakaguchi. 2021. "Remapping of Adult-Born Neuron Activity during Fear Memory Consolidation in Mice" International Journal of Molecular Sciences 22, no. 6: 2874. https://doi.org/10.3390/ijms22062874

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