Neural Circuitry–Neurogenesis Coupling Model of Depression
Abstract
:1. Introduction
2. Activity-Dependent Adult Neurogenesis and Framework of Neural Circuitry–Neurogenesis Coupling Model of Depression
3. Entorhinal–Hippocampal Circuitry and Neurogenesis in Memory
3.1. Supportive Findings from Human Studies
3.2. Supportive Findings from Animal Studies
4. Entorhinal–Hippocampal Circuitry and Neurogenesis in Pattern Separation
4.1. Supportive Findings from Human Studies
4.2. Supportive Findings from Animal Studies
5. Entorhinal–Hippocampal Circuitry and Neurogenesis in Mood Regulation
Supportive Findings from Animal Studies
6. Suggestions for Advancing the Neural Circuitry–Neurogenesis Coupling Model of Depression
7. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Stimulation Approach | Subject | Depression-Related Phenotype | Target of Stimulation | Consequence in Hippocampus | Behavioral Task | Work * |
---|---|---|---|---|---|---|
DBS | Human | Spatial memory | Entorhinal cortex | Hippocampal theta rhythm, resetted | Spatial navigation test | 13 |
DBS | Mouse | Spatial memory | Entorhinal cortex | Dentate gyrus neurogenesis, enhanced | Morris water maze test | 12 |
DBS | Rat | Spatial memory | Entorhinal cortex | Dentate gyrus neurogenesis, enhanced | Morris water maze test | 15 |
Optogenetics | Transgenic rat | Temporal memory | Medial entorhinal cortex | Hippocampal CA1 temporal coding activity, enhanced | Object–treadmill–maze test | 48 |
Chemogenetics | Transgenic mouse | Pattern separation | Entorhinal glutamatergic afferents | Dentate gyrus neurogenesis, enhanced | Fear-context conditioning test | 16 |
Chemogenetics | Transgenic mouse | Depressive-like behaviors | Entorhinal glutamatergic afferents | Dentate gyrus neurogenesis, enhanced | Forced swimming test Novelty-suppressed feeding test | 16 |
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Kim, I.B.; Park, S.-C. Neural Circuitry–Neurogenesis Coupling Model of Depression. Int. J. Mol. Sci. 2021, 22, 2468. https://doi.org/10.3390/ijms22052468
Kim IB, Park S-C. Neural Circuitry–Neurogenesis Coupling Model of Depression. International Journal of Molecular Sciences. 2021; 22(5):2468. https://doi.org/10.3390/ijms22052468
Chicago/Turabian StyleKim, Il Bin, and Seon-Cheol Park. 2021. "Neural Circuitry–Neurogenesis Coupling Model of Depression" International Journal of Molecular Sciences 22, no. 5: 2468. https://doi.org/10.3390/ijms22052468