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Review

Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders

1
Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka 812-8582, Japan
2
Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Science, Kyushu University, Maidashi 3-1-1, Higashi-Ku, Fukuoka 812-8582, Japan
3
Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8577, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Marco Tatullo
Int. J. Mol. Sci. 2021, 22(5), 2269; https://doi.org/10.3390/ijms22052269
Received: 3 February 2021 / Revised: 18 February 2021 / Accepted: 23 February 2021 / Published: 25 February 2021
A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, osteogenic, chondrogenic, and neurogenic potential. Teeth containing viable cells are harvested via minimally invasive procedures, based on various clinical diagnoses, but then usually discarded as medical waste, indicating the relatively low ethical considerations to reuse these cells for medical applications. Previous studies have demonstrated that stem cells derived from healthy subjects are an excellent source for cell-based medicine, tissue regeneration, and bioengineering. Furthermore, stem cells donated by patients affected by genetic disorders can serve as in vitro models of disease-specific genetic variants, indicating additional applications of these stem cells with high plasticity. This review discusses the benefits, limitations, and perspectives of patient-derived dental pulp stem cells as alternatives that may complement other excellent, yet incomplete stem cell models, such as induced pluripotent stem cells, together with our recent data. View Full-Text
Keywords: dental pulp stem cells; disease model; mesenchymal stem cells; stem cells from human exfoliated deciduous teeth dental pulp stem cells; disease model; mesenchymal stem cells; stem cells from human exfoliated deciduous teeth
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MDPI and ACS Style

Masuda, K.; Han, X.; Kato, H.; Sato, H.; Zhang, Y.; Sun, X.; Hirofuji, Y.; Yamaza, H.; Yamada, A.; Fukumoto, S. Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders. Int. J. Mol. Sci. 2021, 22, 2269. https://doi.org/10.3390/ijms22052269

AMA Style

Masuda K, Han X, Kato H, Sato H, Zhang Y, Sun X, Hirofuji Y, Yamaza H, Yamada A, Fukumoto S. Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders. International Journal of Molecular Sciences. 2021; 22(5):2269. https://doi.org/10.3390/ijms22052269

Chicago/Turabian Style

Masuda, Keiji, Xu Han, Hiroki Kato, Hiroshi Sato, Yu Zhang, Xiao Sun, Yuta Hirofuji, Haruyoshi Yamaza, Aya Yamada, and Satoshi Fukumoto. 2021. "Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders" International Journal of Molecular Sciences 22, no. 5: 2269. https://doi.org/10.3390/ijms22052269

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